1887

Abstract

SUMMARY

The distribution of rabies virus, interferon and interferon-mediated enzymes, pppA(2′p5′A) synthetase (2–5A synthetase) and poly(rI).poly(rC)-Sepharose-bound protein kinase, was studied in different regions of the brains of rabies virus-infected rats. A broad range of virus infectivity was found in the brain stem, cerebellum, cortex, hippocampus and striatum. Similarly, the levels of interferon were variable (2500 to 60000 units/mg protein in tissue extracts) in the different brain regions studied but were unrelated to the corresponding infectivities. The level of 2–5A synthetase and protein kinase was enhanced several-fold in the individual brain regions and the degree of such enhancement was correlated with the level of interferon.

Keyword(s): brain , IFN and rabies virus
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/content/journal/jgv/10.1099/0022-1317-65-5-995
1984-05-01
2022-01-23
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References

  1. Atanasiu P., Perrin P. 1979; Micromethode immunoenzymatique de titrage des anticorps antirabiques: utilisation de la glycoproteine rabique et de la proteine A conjuguee a la peroxydase. Annales de Microhiologie 130A:257–268
    [Google Scholar]
  2. Finter N. B. 1965; A comparison of the amounts of mouse interferon obtained from different sources. Nature, London 206:597–599
    [Google Scholar]
  3. Hovanessian A. G., Riviere Y. 1980; Interferon-mediated induction of 2–5A synthetase and protein kinase in the liver and spleen of mice infected with Newcastle disease virus or injected with poly(I)-poly(C). Annales de Virologie 131E:501–516
    [Google Scholar]
  4. Hovanessian A. G., Brown R., Kerr I. M. 1977; Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells. Nature, London 268:537–539
    [Google Scholar]
  5. Hovanessian A. G., Riviere Y., Krust B. 1983; Assay of interferon-mediated protein kinase activity from plasma and tissue extracts. Analytical Biochemistry 129:349–356
    [Google Scholar]
  6. Konig J. F. R., Klippel R. A. 1967 The Rat Brain:A Stereotaxic Atlas New York: R. E. Krieger;
    [Google Scholar]
  7. Krust B., Riviere Y., Hovanessian A. G. 1982; p67 kinase in different tissues and plasma of control and interferon-treated mice. Virology 120:240–246
    [Google Scholar]
  8. Luby J. P., Sanders C. V., Sulkin S. E. 1971; Interferon assays and quantitative virus determinations in fatal infection in man with western equine encephalomyelitis virus. American Journal of Tropical Medicine and Hygiene 20:765–769
    [Google Scholar]
  9. Marcovistz R., Tsiang H., Hovanessian A. G. 1984; Production and action of interferon in mice infected with rabies virus. Annales de Virologie (in press)
    [Google Scholar]
  10. Matsumoto S. 1962; Electron microscopy of nerve cells infected with street rabies virus. Virology 17:198–202
    [Google Scholar]
  11. Riviere Y., Gresser I., Guillon J.-C., Tovey M. G. 1977; Inhibition by anti-interferon serum of lymphocytic choriomeningitis disease in suckling mice. Proceedings of the National Academy of Sciences, U.S.A 74:2135–2139
    [Google Scholar]
  12. Stewart W. E. II, Sulkin S. E. 1966; Interferon production in hamsters experimentally infected with rabies virus. Proceedings of the Society for Experimental Biology and Medicine 123:650–654
    [Google Scholar]
  13. Tongaonkar S. S., Ghosh S. N. 1973; Production of interferon by arboviruses in suckling mouse brains. Current Science 42:680–688
    [Google Scholar]
  14. Tsiang H. 1982; Neuronal function impairment in rabies-infected rat brain. Journal of General Virology 61:277281
    [Google Scholar]
  15. Tsiang H., Koulakoff A., Bizzini B., Berwald-Netter Y. 1983; Neurotropism of rabies virus -an in vitro study. Journal of Neuropathology 42:439–452
    [Google Scholar]
  16. Vilcek J. 1964; Production of interferon by newborn and adult mice infected with Sindbis virus. Virology 22:651–652
    [Google Scholar]
  17. Wiktor T. J., Koprowski H., Rorke L. B. 1972; Localized rabies infection in mice. Proceedings of the Society for Experimental Biology and Medicine 140:759–764
    [Google Scholar]
  18. Wood J. N., Hovanessian A. G. 1979; Interferon enhances 2–5A synthetase in embryonal carcinoma cells. Nature, Ixmdon 282:74–76
    [Google Scholar]
  19. World Health Organization 1973; Laboratory techniques in rabies. WHO Monograph Series no. 23 Edited by Kaplan M. M., Koprowski H.
    [Google Scholar]
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