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1887

Abstract

SUMMARY

Acute-phase stool samples collected from hepatitis cases during outbreaks of water-borne epidemic hepatitis were examined by immune electron microscopy (IEM). Spherical virus-like particles (27nm in diameter) were visualized in the stool of a hepatitis patient with serological evidence of non-A, non-B (NANB) hepatitis. The IEM demonstrated serological specificity of the antigen with the patient’s own convalescent serum as well as a known pool of NANB hepatitis convalescent sera. It is suggested that these virus-like particles may be the aetiological agent of faeco-orally transmitted NANB epidemic hepatitis in India.

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/content/journal/jgv/10.1099/0022-1317-65-5-1005
1984-05-01
2025-11-08

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References

  1. Balayan M. S., Andjaparidze A. G., Savinskaya S. S., Ketiladze E. S., Braginsky D. N., Savinov A. P., Poleschuk V. F. 1983; Evidence for a virus in Non-A, Non-B hepatitis transmitted via faecal-oral route. Intervirology 20:23–31
    [Google Scholar]
  2. Dienstag J. L., Stevens C. E., Szmuness W. 1981; The epidemiology of Non-A, Non-B hepatitis: emerging patterns. In Non-A, Non-B Hepatitis pp 119–138 Edited by Gerety R. J. New York: Academic Press;
    [Google Scholar]
  3. Kapikian A. Z., Wyatt R. G., Dolin R., Thornhill T. S., Kalica A. R., Chanock R. M. 1972; Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious non-bacterial gastroenteritis. Journal of Virology 10:1075–1081
    [Google Scholar]
  4. Khuroo M. S. 1980; Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. American Journal of Medicine 68:818–824
    [Google Scholar]
  5. Wong D. C., Purcell R. H., Sreenivasan M. A., Prasad S. R., Pavri K. M. 1980; Epidemic and endemic hepatitis in India: evidence for Non-A, Non-B hepatitis virus aetiology. Lancet ii:876–879
    [Google Scholar]
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