1887

Abstract

Summary

A single injection of 1 mg dextran sulphate 500 per mouse considerably prolonged incubation times and produced survivors, even when given 3 days after intravenous or intraperitoneal scrapie infection. Since this compound could be detected in mononuclear phagocytes of spleen and lymph nodes for up to 7 months, it is suggested that it impairs a particular step in the infectious process in these cells of the lymphoreticular system. Blockage of the reticuloendothelial system by trypan blue and silica did not alter the pathogenesis.

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/content/journal/jgv/10.1099/0022-1317-65-2-423
1984-02-01
2019-11-14
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-2-423
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