Polypeptide Specificity of the Early Antibody Response Following Primary and Recurrent Genital Herpes Simplex Virus Type 2 Infections Free

Abstract

SUMMARY

Relative IgG titres to specific viral proteins in acute and convalescent sera from patients with primary and recurrent genital herpes simplex virus type 2 (HSV-2) infections were determined using an immunoblot assay. Patients with recurrent genital infections generally had high titres of antibody reactive with two of the three major viral glycoproteins (gD and gG) as well as with several viral capsid proteins in both acute and convalescent sera. In contrast, patients experiencing primary genital HSV-2 infections exhibited marked differences in the polypeptide reactivity profiles of acute and convalescent sera. Of particular interest was the observation that the earliest and strongest antibody response was directed not against the viral glycoproteins but rather to an internal capsid protein(s) of HSV-2.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-65-10-1839
1984-10-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/65/10/JV0650101839.html?itemId=/content/journal/jgv/10.1099/0022-1317-65-10-1839&mimeType=html&fmt=ahah

References

  1. Bishop O. A., Glorioso J. C., Schwartz S. A. 1983; Relationship between expression of herpes simplex virus glycoproteins and susceptibility of target cells to human natural killer activity. Journal of Experimental Medicine 157:1544–1561
    [Google Scholar]
  2. Braun D. K., Roizman B., Pereira L. 1984; Characterization of post-translational products of herpes simplex virus gene 35 proteins binding to the surfaces of full capsids but not empty capsids. Journal of Virology 49:142–153
    [Google Scholar]
  3. Carter V. C., Schaffer P. A., Tevethia S. S. 1981; The involvement of herpes simplex virus type 1 glycoproteins in cell mediated immunity. Journal of Immunology 126:1655–1660
    [Google Scholar]
  4. Eberle R., Mou S.-W. 1983; Relative titres of antibodies to individual polypeptide antigens of herpes simplex virus type 1 in human sera. Journal of Infectious Diseases 148:436–444
    [Google Scholar]
  5. Graves M., Griffin D. E., Johnson R. T., Hirsch R. L., Desoriano I. L., Roedenbeck S., Vasiberg A. 1984; Development of antibody to measles virus polypeptides during complicated and uncomplicated measles virus infections. Journal of Virology 49:409–412
    [Google Scholar]
  6. Heilman C. J., Zweig M., Stephenson J. R., Hampar B. 1979; Isolation of a nucleocapsid polypeptide of herpes simplex virus types 1 and 2 possessing immunologically type-specific and cross-reactive determinants. Journal of Virology 29:34–42
    [Google Scholar]
  7. Heilman C. J., Zweig M., Hampar B. 1981; Herpes simplex virus types 1 and 2 intracellular p40: type-specific and cross-reactive antigenic determinants on peptides generated by partial proteolysis. Journal of Virology 40:508–515
    [Google Scholar]
  8. Heine J. W., Spear P. G., Roizman B. 1972; Proteins specified by herpes simplex virus. VI. Viral proteins in the plasma membrane. Journal of Virology 9:431–439
    [Google Scholar]
  9. Lawman M. J. P., Courtney R. J., Eberle R., Schaffer P. A., O’Hara M. K., Rouse B. T. 1980; Cell-mediated immunity to herpes simplex virus: specificity of cytotoxic T cells. Infection and Immunity 30:451–461
    [Google Scholar]
  10. Norrild B., Shore S. L., Nahmias A. J. 1979; Herpes simplex virus glycoproteins: participation of individual herpes simplex virus type 1 glycoprotein antigens in immunocytolysis and their correlation with previously identified glycopolypeptides. Journal of Virology 32:741–748
    [Google Scholar]
  11. Olshevsky U., Becker Y. 1972; Surface glycopeptides in the envelope of herpes simplex virions. Virology 50:277–279
    [Google Scholar]
  12. Poewll K. L., Buchan A., Sim C., Watson D. H. 1974; Type-specific protein in herpes simplex virus envelope reacts with neutralizing antibodies. Nature, London 249:360–361
    [Google Scholar]
  13. Preston V. G., Coates J. A. V., Rixon F. J. 1983; Identification and characterization of a herpes simplex virus gene product required for encapsidation of virus DNA. Journal of Virology 45:1056–1064
    [Google Scholar]
  14. Sim C., Watson D. H. 1973; The role of type specific and cross reacting structural antigens in the neutralization of herpes simplex virus types 1 and 2. Journal of General Virology 19:217–233
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-10-1839
Loading
/content/journal/jgv/10.1099/0022-1317-65-10-1839
Loading

Data & Media loading...

Most cited Most Cited RSS feed