1887

Abstract

Summary

Culture supernatants of permissive and non-permissive cells infected with human cytomegalovirus (HCMV) contain a growth factor that enhances the DNA synthesis and mitotic activity of target cells. This cytomegalovirus growth factor (CMV-GF) is a heat-stable, acid-labile polypeptide that is sensitive to trypsin and dithiothreitol. CMV-GF is an early product of the infected cells and defective virions are primarily responsible for its induction. Microtubule depolymerization is necessary for the induction of DNA synthesis by the CMV-GF, since taxol, an inhibitor of microtubule depolymerization, blocks its effect.

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/content/journal/jgv/10.1099/0022-1317-65-10-1833
1984-10-01
2019-10-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-10-1833
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