1887

Abstract

SUMMARY

Evidence is presented that defective interfering (DI) Semliki Forest virus (SFV) can modulate the systemic infection in mice initiated by intraperitoneal inoculation of 10 LD SFV. Either the mean time of death was delayed or mice failed completely to develop any sign of disease. This prophylactic activity of DI virus was not due to the stimulation of an adaptive immune response since an equivalent amount of non-infectious virus antigen did not change the course of disease.

Keyword(s): DI virus , modulation , pathogenicity and SFV
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-65-10-1827
1984-10-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/65/10/JV0650101827.html?itemId=/content/journal/jgv/10.1099/0022-1317-65-10-1827&mimeType=html&fmt=ahah

References

  1. Allner K., Bradish C. J., Fitzgeorge R., Nathanson N. 1974; Modifications by sodium auro-thio-malate of the expression of virulence in mice by defined strains of Semliki Forest virus. Journal of General Virology 24:221–228
    [Google Scholar]
  2. Barrett A. D. T., Dimmock N. J. 1984a; Properties of host and virus which influence defective interfering virus-mediated protection of mice against Semliki Forest virus lethal encephalitis. Archives of Virology 81:185–188
    [Google Scholar]
  3. Barrett A. D. T., Dimmock N. J. 1984a; Modulation of Semliki Forest virus-induced infection of mice by defective interfering virus. Journal of Infectious Diseases 150 (in press)
    [Google Scholar]
  4. Barrett A. D. T., Dimmock N. J. 1984c; Variation in homotypic and heterotypic interference by defective interfering virus derived from different strains of Semliki Forest virus and from Sindbis virus. Journal of General Virology 65:1119–1122
    [Google Scholar]
  5. Barrett A. D. T., Crouch C. F., Dimmock N. J. 1981; Assay of defective interfering Semliki Forest virus by the inhibition of synthesis of virus-specified RNAs. Journal of General Virology 54:273–280
    [Google Scholar]
  6. Barrett A. D. T., Crouch C. F., Dimmock N. J. 1984; Defective interfering Semliki Forest virus populations are biologically and physically heterogeneous. Journal of General Virology 65:1273–1283
    [Google Scholar]
  7. Bradish C. J., Allner K. 1972; The early responses of mice to respiratory or intraperitoneal infection by defined strains of Semliki Forest virus. Journal of General Virology 15:205–218
    [Google Scholar]
  8. Bradish C. I., Allner K., Fitzgeorge R. 1975; Immunomodification and the expression of virulence in mice by defined strains of Semliki Forest virus: the effects of cyclophosphamide. Journal of General Virology 28:225–237
    [Google Scholar]
  9. Clarke D. H., Casals J. 1958; Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. American Journal of Tropical Medicine and Hygiene 7:561–573
    [Google Scholar]
  10. Crouch C. F., Mackenzie A., Dimmock N. I. 1982; The effect of defective interfering Semliki Forest virus on the histopathology of infection with virulent Semliki Forest virus in mice. Journal of Infectious Diseases 146:411–416
    [Google Scholar]
  11. Dimmock N. J., Kennedy S. I. T. 1978; Prevention of death in Semliki Forest virus-infected mice by administration of defective-interfering Forest virus. Journal of General Virology 39:231–242
    [Google Scholar]
  12. Doyle M., Holland J. J. 1973; Prophylaxis and immunisation in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus. Proceedings of the National Academy of Sciences, U. S. A 70:2105–2108
    [Google Scholar]
  13. Fultz P. N., Shadduck J. A., Kang C.-Y., Streilein J. W. 1982; Mediators of protection against lethal systemic vesicular stomatitis virus infection in hamsters. Defective interfering particles, polyinosinate-polycytidylate and interferon. Infection and Immunity 37:679–686
    [Google Scholar]
  14. Gates M. C., Sheahan B. I., Atkins G. I. 1984; The pathogenicity of the M9 mutant of Semliki Forest virus in immune-compromised mice. Journal of General Virology 65:73–80
    [Google Scholar]
  15. Holland J. J., Villarreal L. P. 1975; Purification of defective interfering T particles of vesicular stomatitis and rabies viruses generated in vivo in brains of newborn mice. Virology 67:438–449
    [Google Scholar]
  16. Holland J. J., Kennedy S. I. T., Semler B. L., Jones C. L., Roux L., Grabau E. A. 1980; Defective interfering RNA viruses and the host cell response. In Comprehensive Virology vol 16 pp 137–192 Edited by Fraenkel-Conrat H., Wagner R. R. New York: Plenum Press;
    [Google Scholar]
  17. Huang A. S., Baltimore D. 1970; Defective viral particles and viral disease processes. Nature, London 226:325–327
    [Google Scholar]
  18. Huang A. S., Baltimore D. 1977; Defective interfering animal viruses. In Comprehensive Virology vol 10 pp 73–146 Edited by Fraenkel-Conrat H., Wagner R. R. New York: Plenum Press;
    [Google Scholar]
  19. Jones C. L., Holland J. J. 1980; Requirements for DI particle prophylaxis against vesicular stomatitis virus infection in vivo. Journal of General Virology 49:215–220
    [Google Scholar]
  20. Kaariainen L., Pettersson R. F., Keranen S., Lehtovaara P., Soderlund H., Ukkonen P. 1981; Multiple structurally related defective interfering RNAs formed during undiluted passages of Semliki Forest virus. Virology 113:686–697
    [Google Scholar]
  21. Mehta S., Webb H. E. 1982; Lysosomal enzyme changes in macrophages from mice given myocrisin and infected with avirulent Semliki Forest virus. British Journal of Experimental Pathology 63:443–446
    [Google Scholar]
  22. Oaten S. W., Jagelman S., Webb H. E. 1980; Further studies of macrophages in relationship to avirulent Semliki Forest virus infections. British Journal of Experimental Pathology 61:150–155
    [Google Scholar]
  23. Pathak S., Webb H. E. 1983; Effect of myocrisin (sodium auro-thio-malate) on the morphogenesis of avirulent Semliki Forest virus in mouse brain: an electron microscopical study. Neuropathology and Applied Neurobiology 9:313–322
    [Google Scholar]
  24. Perrault J. 1981; Origin and replication of defective interfering particles. Current Topics in Microbiology and Immunology 93:151–207
    [Google Scholar]
  25. Pusztai R., Gould E. A., Smith H. 1971; Infection patterns in mice of an avirulent and virulent strain of Semliki Forest virus. British Journal of Experimental Pathology 52:669–677
    [Google Scholar]
  26. Rabinowitz S. G., Huprikar J. 1979; The influence of defective interfering particles of the PR-8 strain of influenza A virus on the pathogenesis of pulmonary infection in mice. Journal of Infectious Diseases 140:305–315
    [Google Scholar]
  27. Rabinowitz S. G., Dal Canto M. C., Johnson T. C. 1977; Infection of the central nervous system produced by mixtures of defective-interfering particles and wild-type vesicular stomatitis virus in mice. Journal of Infectious Diseases 136:59–74
    [Google Scholar]
  28. Soderlund H., Keranen S., Lehtovaara P., Palva L., Pettersson R. F., Kaariainen L. 1981; Structural complexity of defective interfering RNAs of Semliki Forest virus as revealed by analysis of complementary DNA. Nucleic Acids Research 9:3403–3417
    [Google Scholar]
  29. Spandidos D. A., Graham A. F. 1976; Generation of defective virus after infection of newborn rats with reovirus. Journal of Virology 20:234–247
    [Google Scholar]
  30. Von Magnus P. 1951; Propagation of the PR8 strain of influenza A virus in chick embryos. III. Properties of the incomplete virus produced in several passages of undiluted virus. Acta pathologica et microbiologica scandinavica 29:157–181
    [Google Scholar]
  31. Welsh R. M., Lampert P. W., Oldstone M. B. A. 1977; Prevention of virus-induced cerebellar disease by defective interfering lymphocytic choriomeningitis virus. Journal of Infectious Diseases 136:391–399
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-10-1827
Loading
/content/journal/jgv/10.1099/0022-1317-65-10-1827
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error