%0 Journal Article %A Freebeck, Peter C. %A MacLeod, Roderick %A O’Brien, Timothy %T An Ultrastructural Examination of Non-lymphoid Host Cells of Moloney Murine Leukaemia Virus of CFW/D Mice %D 1984 %J Journal of General Virology, %V 65 %N 1 %P 65-71 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-65-1-65 %K distribution %K ultrastructure %K Mo-MuLV %K transmission %I Microbiology Society, %X SUMMARY An ultrastructural examination of various tissues from CFW/D mice, neonatally injected with Moloney murine leukaemia virus (Mo-MuLV) revealed the presence of type C virus particles budding from the membranes of various bone marrow-derived cells, pancreatic acinar cells, beta cells, and submandibular gland acinar cells. These observations indicate that Mo-MuLV has the potential to replicate in non-lymphoid cell types even when acquired post-partum. In the pancreas, a large accumulation of immature and mature viral particles was observed between the cell membranes of the acinar cells and the basal lamina. A similar accumulation of viral particles was observed in the lumina of the acinus of submandibular glands. The role of murine leukaemia viruses as potential mediators of aberrations of non-haemopoietic tissues and an alternative mode of viral transmission are discussed. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-65-1-65