@article{mbs:/content/journal/jgv/10.1099/0022-1317-65-1-65, author = "Freebeck, Peter C. and MacLeod, Roderick and O’Brien, Timothy", title = "An Ultrastructural Examination of Non-lymphoid Host Cells of Moloney Murine Leukaemia Virus of CFW/D Mice", journal= "Journal of General Virology", year = "1984", volume = "65", number = "1", pages = "65-71", doi = "https://doi.org/10.1099/0022-1317-65-1-65", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-65-1-65", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "distribution", keywords = "ultrastructure", keywords = "Mo-MuLV", keywords = "transmission", abstract = "SUMMARY An ultrastructural examination of various tissues from CFW/D mice, neonatally injected with Moloney murine leukaemia virus (Mo-MuLV) revealed the presence of type C virus particles budding from the membranes of various bone marrow-derived cells, pancreatic acinar cells, beta cells, and submandibular gland acinar cells. These observations indicate that Mo-MuLV has the potential to replicate in non-lymphoid cell types even when acquired post-partum. In the pancreas, a large accumulation of immature and mature viral particles was observed between the cell membranes of the acinar cells and the basal lamina. A similar accumulation of viral particles was observed in the lumina of the acinus of submandibular glands. The role of murine leukaemia viruses as potential mediators of aberrations of non-haemopoietic tissues and an alternative mode of viral transmission are discussed.", }