1887

Abstract

Summary

The small chain of influenza virus haemagglutinin, HA was isolated by a selective enzymic removal of HA or by preparative SDS-polyacrylamide gel electrophoresis. Anti-HA specific antisera and monoclonal antibodies were subtype-specific in immunodiffusion tests and radioimmunoassays. These antibodies did not inhibit haemagglutination or haemolysis, did not prevent virus release, did not neutralize infectivity, and HA did not induce a protective immunity. HA-specific antigenic determinants could not be demonstrated on the surface of infected cells. Lymphocytes from pre-immunized mice could not be stimulated by HA to exert a cytotoxic effect.

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/content/journal/jgv/10.1099/0022-1317-65-1-173
1984-01-01
2019-11-13
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-65-1-173
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