1887

Abstract

SUMMARY

The immune response to Japanese encephalitis virus (JEV) was assessed in JEV-infected mice (mothers) and their offspring. The congenitally infected baby mice responded poorly in all assays for cell-mediated immunity. The total number of their splenic cells remained unaltered but the percentage of T cells was significantly reduced; a depressed delayed hypersensitivity response was seen against both homologous (JEV) and heterologous (sheep erythrocytes) antigens. In addition, significantly higher leukocyte migration inhibition (LMI) of spleen cells in the presence of specific antigen was observed. Adult mice infected during pregnancy demonstrated an impaired delayed hypersensitivity response to JEV antigen only. LMI was positive in mothers at 2 weeks post-partum, but not at later periods.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-64-9-2027
1983-09-01
2022-08-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/64/9/JV0640092027.html?itemId=/content/journal/jgv/10.1099/0022-1317-64-9-2027&mimeType=html&fmt=ahah

References

  1. Chaturvedi U. C., Mathur A., Tandon P., Nato S. M., Rajvanshi S., Tandon H. O. 1979; Variable effect on peripheral blood leucocytes during JE virus infection of man. Clinical and Experimental Immunology 38:492–498
    [Google Scholar]
  2. Chong K. T., Mims C. A. 1982; Delayed hypersensitivity to murine cytomegalovirus and its depression during pregnancy. Infection and Immunity 37:54–59
    [Google Scholar]
  3. Cross S. S., Morse H. C. III, Asofsky R. 1976; Neonatal infection with mouse thymic virus: differential effects on T cells mediating the graft-versus-host reaction. Journal of Immunology 117:635–638
    [Google Scholar]
  4. Gehrz R. C., Marker S. C., Knorr S. O., Kalis J. M., Balfour H. H. Jr 1977; Specific cell-mediated immune defects in active cytomegalovirus infection of young children and their mothers. Lancet ii:844–847
    [Google Scholar]
  5. Golub E. S. 1971; Brain-associated theta antigen reactivity of rabbit antimouse brain serum with mouse lymphoid cells. Cellular Immunology 2:353–361
    [Google Scholar]
  6. Liew F. Y., Russell S. M. 1980; Delayed type hypersensitivity to influenza virus: induction of antigen-specific suppressor T cells for delayed-type hypersensitivity to haemagglutinin during influenza virus infection in mice. Journal of Experimental Medicine 151:799–814
    [Google Scholar]
  7. Mathur A., Arora K. L., Chaturvedi U. C. 1981; Congenital infection of mice with Japanese encephalitis virus. Infection and Immunity 34:26–29
    [Google Scholar]
  8. Mathur A., Arora K.L., Chaturvedi U. C. 1982; Transplacental Japanese encephalitis virus (JEV) infection in mice during consecutive pregnancies. Journal of General Virology 59:213–217
    [Google Scholar]
  9. Mathur A., Arora K. L., Chaturvedi U. C. 1983a; Host defence mechanisms against Japanese encephalitis virus infection in mice. Journal of General Virology 64:805–811
    [Google Scholar]
  10. Mathur A., Rawat S., Chaturvedi U. C. 1983b; Induction of suppressor cells in Japanese encephalitis virus-infected mice. British Journal of Experimental Pathology 64:336–343
    [Google Scholar]
  11. Nash A. A., Gell P. G. H., Wildy P. 1981; Tolerance and immunity in mice infected with herpes simplex virus: simultaneous induction of protective immunity and tolerance to delayed type hypersensitivity. Immunology 45:153–159
    [Google Scholar]
  12. Reynolds D. W., Dean P. H., Pass R. F., Alford C. A. 1979; Specific cell-mediated immunity in children with congenital and neonatal cytomegalovirus infection and their mothers. Journal of Infectious Diseases 140:493–499
    [Google Scholar]
  13. Schauf V., Strelkauskas A. J., Deveikis A. 1976; Alteration of lymphocyte subpopulations with cytomegalovirus infection in infancy. Clinical and Experimental Immunology 26:478–483
    [Google Scholar]
  14. Starr S. E., Tolpin M. D., Friedman H. M., Paucker K., Plotkin S. A. 1979; Impaired cellular immunity to cytomegalovirus in congenitally infected children and their mothers. Journal of Infectious Diseases 140:500–505
    [Google Scholar]
  15. Stroop W. G., Baringer J. R. 1982; Persistent, slow and latent viral infections. Progress in Medical Virology 28:1–43
    [Google Scholar]
  16. Tandon P., Chaturvedi U. C., Mathur A. 1979; Differential depletion of T lymphocytes in the spleen of dengue virus-infected mice. Immunology 37:1–6
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-9-2027
Loading
/content/journal/jgv/10.1099/0022-1317-64-9-2027
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error