1887

Abstract

SUMMARY

The presence of a low level of interferon (IFN) activity was demonstrated in aged culture medium of primary chick embryo (CE) cells. The endogenous cytoplasmic level of 2′,5′-oligoadenylate (2′,5′-A) synthetase activity also increased during cell ageing. This increase was suppressed by addition of antiserum against chick IFN. In contrast, anti-chick IFN serum did not inhibit the ageing effect, i.e. the enhanced production of IFN upon induction after a prolonged preincubation of CE cells. This result indicates that the occurrence of the ageing effect is not mediated by the IFN system which had been expressed spontaneously.

Keyword(s): ageing , chick cells , IFN and priming
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/content/journal/jgv/10.1099/0022-1317-64-9-2017
1983-09-01
2022-01-28
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