1887

Abstract

SUMMARY

The sensitivity of ovine choroid plexus cells to the antiviral effects of the three major types of human and other animal interferons (IFNs) was tested. Ovine cells were found to be highly sensitive to the antiviral effects of natural human IFN-α and IFN-β but not IFN-γ. In addition, ovine cells were highly sensitive to recombinant DNA-derived human IFN-α, IFN-β and IFN-γ. Furthermore, ovine cells were more sensitive ( < 0.01) to human IFN-αs than human fibroblasts (trisomic or disomic for chromosome 21) or bovine cells. Moreover, ovine cells were found to be highly sensitive to the three natural types of bovine, caprine, equine and porcine IFN preparations and relatively insensitive to mouse L-cell IFN.

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1983-09-01
2022-01-22
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References

  1. Billiau A., Joniau M., De Somer P. 1973; Mass production of human interferon in diploid cells stimulated by poly-I:C. Journal of General Virology 19:1–8
    [Google Scholar]
  2. Cantell K., Hirvonen S. 1977; Preparation of human leukocyte interferon for clinical use. Texas Reports on Biology and Medicine 35:138–144
    [Google Scholar]
  3. Epstein L. B., Epstein J. C. 1976; Localization of the gene AVG for the antiviral expression of immune and classical interferon to the distal portion of the long arm of chromosome 21. Journal of Infectious Diseases 133:A56–A62
    [Google Scholar]
  4. Goeddel D. V., Yelverton E., Ullrich A., Heyneker H. L., Miozzari G., Holmes W., Seeburg P. H., Dull T., May L., Stebbing N., Crea R., Maeda S., Mccandliss R., Sloma A., Tabor J. M., Cross M., Famillelti P. C., Pestka S. 1980a; Human leukocyte interferon produced by E. coli is biologically active. Nature, London 287:411–416
    [Google Scholar]
  5. Goeddel D. V., Shepard H. M., Yelverton E., Leung D., Crea R. 1980b; Synthesis of human fibroblast interferon by E. coli. Nucleic Acids Research 8:4057–4074
    [Google Scholar]
  6. Gray P. W., Leung D. W., Pennica D., Yelverton E., Najarian R., Simonsen C. C., Derynck R., Sherwood P. J., Wallace D. M., Burger S. L., Levinson A. D., Goeddel D. V. 1982; Expression of human immune interferon cDNA in E. coli and monkey cells. Nature, London 295:503–508
    [Google Scholar]
  7. Gresser I., Bandu T. M., Brouty-Boye D., Tovey M. 1974; Pronounced antiviral activity of human interferon on bovine and porcine cells. Nature, London 251:543–545
    [Google Scholar]
  8. Interferon Nomenclature 1980 Nature, London 286:110
    [Google Scholar]
  9. Rubinstein S., Famillelti P. C., Pestka S. 1981; Convenient assay for interferons. Journal of Virology 37:755–758
    [Google Scholar]
  10. Sakguchi A. Y., Stevenson D., Gordon I. 1982; Species specificity of interferon action: a functioning homospecific nucleus is required for induction of antiviral activity in heterokaryons. Virology 116:441–453
    [Google Scholar]
  11. Stewart W. E. II 1979 The Interferon System Vienna & New York: Springer-Verlag;
    [Google Scholar]
  12. Torchio C., Trowbridge R. S. 1977; Ovine cells: their long term cultivation and susceptibility of visna virus. In Vitro 13:252–259
    [Google Scholar]
  13. Weck P. K., Apperson S., May L., Stebbing N. 1981; Comparison of the antiviral activities of various cloned human interferon-α subtypes in mammalian cell cultures. Journal of General Virology 57:233–237
    [Google Scholar]
  14. Wiranowska-Stewart M., Stewart W. E. II 1981; Determination of human leukocyte populations involved in production of interferons alpha and gamma. Journal of Interferon Research 1:233–244
    [Google Scholar]
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