1887

Abstract

SUMMARY

After intracerebral inoculation of adult C3H mice, the ‘docile’ strain of lymphocytic choriomeningitis (LCM) virus multiplied to high titre in several visceral organs. Although the virus content of lung, liver, spleen and brain was high, these mice did not die but became long-term carriers of the virus. Injection of mice with the same dose of the ‘aggressive’ strain of LCM virus resulted in much lower virus titres in these organs; nevertheless, 100% of the mice died within 7 to 9 days. The results presented here show that mice infected with the ‘aggressive’ virus do not die if treated with anti-interferon globulin. Under these conditions the titres of ‘aggressive’ virus were as high in the different organs as in mice injected with the ‘docile’ virus. These results are consistent with the hypothesis that inhibition of LCM virus multiplication in various organs by interferon results in a lethal disease. The possible mechanisms underlying this seemingly paradoxical phenomenon are discussed.

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1983-08-01
2024-04-19
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References

  1. Cole G. A., Nathanson N., Prendergast R. A. 1972; Requirement for θ bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. Nature, London 238:335–337
    [Google Scholar]
  2. Gresser I., Tovey M. G., Bandu M.T., Maury C., Brouty-Boye D. 1976a; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. Journal of Experimental Medicine 144:1305–1315
    [Google Scholar]
  3. Gresser I., Tovey M. G., Maury C., Bandu M.T. 1976b; Role of interferon in pathogenesis of viral diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses. Journal of Experimental Medicine 144:1316–1323
    [Google Scholar]
  4. Gresser I., Morel-Maroger L., Verroust P., Riviere Y., Guillon J. C. 1978; Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus. Proceedings of the National Academy of Sciences, U. S. A 75:3413–3416
    [Google Scholar]
  5. Jacobson S. 1980 Properties of in vitro and in vivo long term persistent infections with lymphocytic choriomeningitis virus Ph. D thesis Rensselaer Polytechnic Institute; Troy, New York:
    [Google Scholar]
  6. Jacobson S., Pfau C. J. 1980; Viral pathogenesis and resistance to defective interfering particles. Nature, London 283:311–313
    [Google Scholar]
  7. Jacobson S., Dutko F. J., Pfau C. J. 1979; Determinants of spontaneous recovery and persistence in MDCK cells infected with lymphocytic choriomeningitis virus. Journal of General Virology 44:113–121
    [Google Scholar]
  8. Jacobson S., Friedman R. M., Pfau C. J. 1981; Interferon induction by lymphocytic choriomeningitis viruses correlates with maximum virulence. Journal of General Virology 57:275–283
    [Google Scholar]
  9. Pfau C. J., Valenti J. K., Jacobson S., Pevear D. C. 1982a; Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities. Infection and Immunity 36:598–602
    [Google Scholar]
  10. Pfau C. J., Valenti J. K., Pevear D. C., Hunt K. D. 1982b; Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated infections. Journal of Experimental Medicine 156:79–89
    [Google Scholar]
  11. Riviere Y., Gresser I., Guillon J. C., Tovey M. G. 1977; Inhibition by anti-interferon serum of lymphocytic choriomeningitis disease in suckling mice. Proceedings of the National Academy of Sciences, U. S. A 74:2135–2139
    [Google Scholar]
  12. Saron M. F., Riviere Y., Gresser I., Guillon J. C. 1982a; Prevention par les globulines anti-interferon de la mortalite des souris infectees par le virus de la choriomeningite lymphocytaire. I. Lesions histologiques, titres seriques du virus et de l’interferon. Annales de Virologie 132E:241–253
    [Google Scholar]
  13. Saron M. F., Riviere Y., Hovanssian A. G., Guillon J. C. 1982b; Chronic production of interferon in carrier mice congenitally infected with lymphocytic choriomeningitis virus. Virology 117:253–256
    [Google Scholar]
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