@article{mbs:/content/journal/jgv/10.1099/0022-1317-64-8-1823, author = "Cantell, K. and Hirvonen, S. and Pyhälä, L. and De Reus, A. and Schellekens, H.", title = "Circulating Interferon in Rabbits and Monkeys after Administration of Human Gamma Interferon by Different Routes", journal= "Journal of General Virology", year = "1983", volume = "64", number = "8", pages = "1823-1826", doi = "https://doi.org/10.1099/0022-1317-64-8-1823", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-8-1823", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "monkeys", keywords = "interferon (HuIFN-γ)", keywords = "pharmacokinetics", keywords = "rabbits", abstract = "SUMMARY Rabbits and rhesus monkeys were injected with 3 × 105 units of human gamma interferon (IFN) prepared in human leukocyte suspensions. Circulating IFN was detected up to 4 h after intravenous administration. Intramuscular injection maintained a relatively stable serum IFN level of about 50 units/ml for 7 to 9 h. The results in both species were similar. Little or no circulating IFN was detected after subcutaneous injection of 3 × 105 units, but 1.5 × 106 units maintained about 50 units per ml of serum for 30 h. Pharmacokinetically, human gamma IFN resembled human alpha interferons rather than human beta IFN.", }