1887

Abstract

Summary

A modified human interferon-α was produced in cells infected with phage M13 mp7 containing an interferon-α gene. After purification by immunochromatography with the monoclonal antibody NK2, the N-terminal amino acid sequence was determined. The N-terminal methionine was absent but an additional sequence of 18 amino acids at the N-terminus was retained. The modified interferon-α was indistinguishable from authentic interferon-α in its ability to activate natural killer cells, to slow the growth of Daudi cells, and to confer virus resistance on heterologous cells.

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/content/journal/jgv/10.1099/0022-1317-64-8-1815
1983-08-01
2019-10-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-8-1815
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