%0 Journal Article %A Alatossava, T. %A Juvonen, T. %A Huhtinen, R.-L. %T Effect of Cadmium on the Infection of Lactobacillus lactis by Bacteriophage LL-H %D 1983 %J Journal of General Virology, %V 64 %N 7 %P 1623-1627 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-64-7-1623 %K phage DNA replication %K multiplication %K Lactobacillus bacteriophage %K cadmium %I Microbiology Society, %X SUMMARY The infectivity of Lactobacillus lactis bacteriophage LL-H was shown to be calcium-dependent. Of 10 different divalent cations screened, cadmium specifically decreased the infectivity of LL-H in the presence of calcium. At 1 to 2 mm, CdCl2 resulted in a decrease of the burst size of about 2.5- to 4-fold. Cd2+ was shown to reduce specifically the level of total phage DNA synthesis, resulting in a reduced progeny phage yield. Moreover, Cd2+ had the most profound irreversible effect on progeny phage production between 20 and 60 min after LL-H infection. This paralleled the beginning of phage DNA synthesis. Possible modes of action of Cd2+ on phage DNA replication are discussed. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-7-1623