RT Journal Article SR Electronic(1) A1 Yourist, J. E. A1 Haines, H. G. A1 Miller, K. D.YR 1983 T1 Inhibition of Herpes Simplex Virus Replication by Cobra α-Neurotoxoid JF Journal of General Virology, VO 64 IS 7 SP 1475 OP 1481 DO https://doi.org/10.1099/0022-1317-64-7-1475 PB Microbiology Society, SN 1465-2099, AB SUMMARY A peptide, prepared by gentle oxidative detoxification of a methionine-free cobra α-neurotoxin, was evaluated for antiviral activities in vivo and in vitro. When added to BHK cells before infection the peptide reduced herpes simplex virus type 1 (HSV-1)-induced TCD50 in a dose- and time-dependent manner. The antiviral effect was also expressed on initiation of cell treatment 1 h after infection if the peptide was left in contact with cells. Single, intracerebral doses of the toxoid in suckling mice significantly increased 50% survival times, and reduced virus replication in the infected brain tissues. Cutaneous lesions and resultant scar formation induced by HSV-1 in hairless mice were also significantly reduced by subcutaneous peptide injections., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-7-1475