1887

Abstract

SUMMARY

Six sheep persistently infected with visna virus were studied for 4 1/2 to 5 3/4 years until they became ill. Virus was isolated at intervals from peripheral blood leukocytes and cerebrospinal fluid (CSF), and at the time of sacrifice from various parts of the brain and the lungs. Both brain and lungs showed lesions typical of advanced visna/maedi. All the sheep formed antibodies in sera and CSF. Virus isolates from each sheep were tested in neutralization tests against sera and CSF collected from the same animal. In one sheep all isolates were found to be identical to the inoculated virus by this test. In each of the other sheep an antigenic variant emerged from 1 to 3 years after inoculation and remained in circulation even after the formation of autologous antibodies. In one case a variant was isolated from the lungs, whereas in all cases the virus isolated from the brain was identical to the inoculated virus. The results show that antigenic variants are rare in visna and do not seem to have a role in the pathogenesis of the disease.

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/content/journal/jgv/10.1099/0022-1317-64-7-1427
1983-07-01
2024-04-18
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References

  1. Brown H. R., Thormar H. 1975; Persistence of visna virus in murine and hamster cell cultures without the appearance of cell transformation. Microbios 13:51–60
    [Google Scholar]
  2. De Boer G. F. 1975; Zwoegerziekte virus, the causative agent for progressive interstitial pneumonia (maedi) and meningo-leukoencephalitis (visna) in sheep. Research in Veterinary Science 18:15–25
    [Google Scholar]
  3. Georgsson G., Palsson P. A., Panitch H., Nathanson N., Petursson G. 1977; The ultrastructure of early visna lesions. Acta neuropathologica 37:127–135
    [Google Scholar]
  4. Gudnadottir M. 1974; Visna-maedi in sheep. Progress in Medical Virology 18:336–349
    [Google Scholar]
  5. Lin F. H., Thormar H. 1971; Characterization of ribonucleic acid from visna virus. Journal of Virology 7:582587
    [Google Scholar]
  6. Lutley R., Petursson G., Palsson P. A., Georgsson G., Klein J., Nathanson N. 1983; Antigenic drift in visna: virus variation during long-term infection of sheep. Journal of General Virology 64:1433–1440
    [Google Scholar]
  7. Narayan O., Griffin D. E., Clements J. E. 1978; Visna mutation during ‘slow infection’: temporal development and characterization of mutants of visna virus recovered from sheep. Journal of General Virology 41:343–352
    [Google Scholar]
  8. Nathanson N., Panitch H., Palsson P. A., Petursson G., Georgsson G. 1976; Pathogenesis of visna. II. Effect of immunosuppression upon early central nervous system lesions. iMboratory Investigation 35:444–451
    [Google Scholar]
  9. Petursson G., Nathanson N., Georgsson G., Panitch H., Palsson P. A. 1976; Pathogenesis of visna. I.Sequential virologic, serologic, and pathologic studies. Laboratory Investigation 35:402–412
    [Google Scholar]
  10. Petursson G., Nathanson N., Lutley R. E. 1981; Antigenic variation during visna virus infection. International Virology 5:121
    [Google Scholar]
  11. Thormar H. 1963; Neutralization of visna virus by antisera from sheep. Journal of Immunology 90:185–192
    [Google Scholar]
  12. Thormar H. 1966; A study of maedi virus. In Lung Tumours in Animals pp 393–402 Edited by Severi L. Perugia, Italy: University of Perugia Publication;
    [Google Scholar]
  13. Thormar H., Helgadottir H. 1965; A comparison of visna and maedi viruses. II. Serological relationships. Research in Veterinary Science 6:456–465
    [Google Scholar]
  14. Thormar H., Palsson P. A. 1967; Visna and maedi – two slow infections of sheep and their etiological agents. In Perspectives in Virology vol 5: pp 291–308 Edited by Pollard M. New York: Academic Press;
    [Google Scholar]
  15. Thormar H., Kristensson K., Lin F. H., Wisniewski H. M. 1980; Cellular immune response in rabbits immunized with purified visna virus. Acta pathologica et microbiologica scandinavica 88C:173–177
    [Google Scholar]
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