A Comparison of the Terminal Protein and Hexon Polypeptides of Avian and Human Adenoviruses

It was found that the virion terminal protein of chick embryo lethal orphan (CELO) virus had a molecular weight of 46000, and the hexon a molecular weight of 100000. 125I-labelled tryptic and chymotryptic peptide maps of the hexons and terminal proteins from CELO virus and human adenovirus type 5 (Ad5) differed. However, limited proteolysis of CELO virus and Ad5 terminal proteins by protease V8 showed similarities which were not detected in the case of the two hexons.