RT Journal Article SR Electronic(1) A1 Bauer, GeorgYR 1983 T1 Quantitative Analysis of the Cooperative Effect between Inducers of Epstein–Barr Virus Antigen Synthesis JF Journal of General Virology, VO 64 IS 6 SP 1337 OP 1346 DO https://doi.org/10.1099/0022-1317-64-6-1337 PB Microbiology Society, SN 1465-2099, AB SUMMARY Induction of Epstein–Barr virus antigens in Raji cells by 12-O-tetradecanoylphorbol 13-acetate (TPA), 5′-iodo-2′-deoxyuridine (IUdR), n-butyric acid (n-BA) antibody to IgM (anti-IgM) and a recently described serum factor was studied after single applications of individual inducers or of their combinations. Whereas individual inducers led to activation only in a limited number of cells, certain combinations of inducers greatly enlarged the reactive cell population. In synergistically acting combinations of drugs, the dose necessary for half-maximal induction of the first inducer was shifted to a much lower value by the second inducer. The serum factor cooperated with any of the four inducers TPA, IUdR, anti-IgM and n-butyric acid, whereas TPA only interacted with IUdR and n-butyric acid. The effects of the serum factor and of TPA showed some similarities but were not identical, whereas IUdR and n-BA showed identical effects., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-6-1337