1887

Abstract

Summary

We report the ultrastructural features associated with wild-type and temperature-sensitive () mutant infection at non-permissive temperature for each of 18 herpes simplex virus type 1 (HSV-1) (strain 17) mutants. The mutants were classified by their ability to induce nucleocapsid-related structures:class I failed to induce any, class II induced empty and partially filled structures while class III induced all of the identified structures including those containing an electron-dense core. The time when expression of the lesion blocked virus replication was estimated for most mutants; this allows both mutant gene expression and the resulting ultrastructural features to be correlated with the sequence of virus replicative events. Three mutant-triggered features not previously described in HSV-1-infected cells were also recognized: a modification of rough endoplasmic reticulum, intranuclear accumulation of enveloped virus particles and cytoplasmic accumulation of novel doughnut-shaped particles having a concentric double ring appearance in thin section.

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/content/journal/jgv/10.1099/0022-1317-64-6-1311
1983-06-01
2019-10-16
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-6-1311
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