1887

Abstract

SUMMARY

Pre- and postnatally acquired protection against herpes simplex virus type 2(HSV-2) infection mediated by maternal antibody was investigated in the newborn mouse. Newborn mice, 2 days old, were inoculated with HSV-2 intraperitoneally after maternal immunization with live or inactivated virus. The survival rates improved in proportion to the maternal neutralizing antibody titres. Ninety-three percent of animals delivered by Caesarean section from immune mothers and suckled by non-immune mothers survived viral infection, whereas 7% of control animals survived. The same was true with animals born to non-immune mothers and nursed by immune mothers. In foetal sera and milk of immunized mice, anti-HSV activity was associated primarily with antibody of the IgG class as measured by enzyme-linked immunosorbent assay (ELISA). In addition, oral administration of antibody conferred protection on newborn mice. These studies indicate that maternal IgG, acquired not only postnatally but also prenatally, plays an important role in protecting newborn mice against HSV infection.

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1983-05-01
2021-10-20
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References

  1. Amstey M. S., Kobos K. 1976; An experimental model for disseminated herpesvirus infection of the neonate. American Journal of Obstetrics and Gynecology 125:40–44
    [Google Scholar]
  2. Baron S., Worthington M. G., Williams J., Gaines I. W. 1976; Postexposure serum prophylaxis of neonatal herpes simplex virus infection of mice. Nature, London 261:505–506
    [Google Scholar]
  3. Berry G. P., Slavin H. B. 1943; Studies on herpetic infection in mice. I. Passive protection against virus inoculated intranasally. Journal of Experimental Medicine 78:305–313
    [Google Scholar]
  4. Georgiades J. A., Montgomery J. M., Hughes T. K., Jensen D., Baron S. 1982; Determinants of protection by human immune globulin against experimental herpes neonatorum. Proceedings of the Society for Experimental Biology and Medicine 170:291–297
    [Google Scholar]
  5. Gilman S. C., Docherty J. J. 1977; Detection of antibodies specific for herpes simplex virus in human sera by the enzyme-linked immunosorbent assay. Journal of Infectious Diseases 136: Supplement 286–293
    [Google Scholar]
  6. Guyer R. L., Koshland M. E., Knopf P. M. 1976; Immunoglobulin binding by mouse intestinal epithelial cell receptors. Journal of Immunology 117:587–593
    [Google Scholar]
  7. Hanshow J. B. 1973; Herpesvirus hominis infection in the fetus and the newborn. American Journal of Diseases of Children 126:546–555
    [Google Scholar]
  8. Hayashida L., Nagafuchi S., Hayashi Y., Mori R., Oda H., Ohtomo N., Tashiro A. 1982; Mechanism of antibody-mediated protection against herpes simplex virus infection in athymic nude mice: requirement of Fc portion of antibody. Microbiology and Immunology 26:497–509
    [Google Scholar]
  9. Head J. R., Beer A. E. 1979; In vivo and in vitro assessment of the immunologic role of leukocytic cells in milk. In Immunology of Breast Milk pp 207–221 Edited by Ogra P. L., Dayton D. New York: Raven Press;
    [Google Scholar]
  10. Hirsch M. S., Zisman B., Allison A. C. 1970; Macrophages and age-dependent resistance to herpes simplex virus in mice. Journal of Immunology 104:1160–1165
    [Google Scholar]
  11. Johnson R. T. 1964; The pathogenesis of herpes virus encephalitis. I. Virus pathways to the nervous system of suckling mice demonstrated by fluorescent antibody staining. Journal of Experimental Medicine 119:343–365
    [Google Scholar]
  12. Kern E. R., Overall J. C. Jr, Glasgow L. A. 1973; Herpesvirus hominis infection in newborn mice. I. An experimental model and therapy with iododeoxyuridine. Journal of Infectious Diseases 128:290–299
    [Google Scholar]
  13. Kistler P., Nitschmann H. 1962; Large scale production of human plasma fractions. Vox sanguinis 7:414–424
    [Google Scholar]
  14. Kohl S., Loo L. S. 1982; Protection of neonatal mice against herpes simplex virus infection: probable in vivo antibody-dependent cellular cytotoxicity. Journal of Immunology 129:370–376
    [Google Scholar]
  15. Kohl S., Pickering L. K., Loo L. S. 1982; Virus-induced colostral cell cytokine stimulation of human leukocyte natural killer cytotoxicity. Infection and Immunity 36:691–695
    [Google Scholar]
  16. Luyet F., Samura D., Soneji A., Markrs M. I. 1975; Passive immunization in experimental Herpesvirus hominis infection of newborn mice. Infection and Immunity 12:1258–1261
    [Google Scholar]
  17. Mori R., Minamishima Y., Tasaki T., Oda H., Takade A. 1973; Hexagonal arrangement of filaments in herpes simplex virus type 2-infected cells. Japanese Journal of Microbiology 17:230–232
    [Google Scholar]
  18. Nagafuchi S., Oda H., Mori R., Taniguchi T. 1979; Mechanism of acquired resistance to herpes simplex virus infection as studied in nude mice. Journal of General Virology 44:715–723
    [Google Scholar]
  19. Nahmias A. J., Josey W. E., Naib Z. M., Freeman M. G., Fernandez R. J., Wheeler J. H. 1971; Perinatal risk associated with maternal genital herpes simplex virus infection. American Journal of Obstetrics and Gynecology 110:825–834
    [Google Scholar]
  20. Oakes J. E., Lausch R. N. 1981; Role of Fc fragments in antibody-mediated recovery from ocular and sub-cutaneous herpes simplex virus infections. Infection and Immunity 33:109–114
    [Google Scholar]
  21. Schreiner R. L., Kleiman M. B., Gresham E. L. 1979; Maternal oral herpes: isolation policy. Pediatrics 63:247–249
    [Google Scholar]
  22. Voller A., Bartlet A., Bidwell D. 1978; Enzyme immunoassays with special reference to ELISA techniques. Journal of Clinical Pathology 31:507–520
    [Google Scholar]
  23. Whitley R. J., Nahmias A. J., Visintine A. M., Fleming C. L., Alford C. A. 1980; The natural history of herpes simplex virus infection of mother and newborn. Pediatrics 66:489–494
    [Google Scholar]
  24. Yeager A. S., Arvin A. M., Urvani L. I., Kemp J. A. III 1980; Relationship of antibody to outcome in neonatal herpes simplex virus infections. Infection and Immunity 29:532–538
    [Google Scholar]
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