RT Journal Article SR Electronic(1) A1 Stannard, Linda M. A1 Hantz, O. A1 Trepo, C.YR 1983 T1 Antigenic Cross-reactions between Woodchuck Hepatitis Virus and Human Hepatitis B Virus Shown by Immune Electron Microscopy JF Journal of General Virology, VO 64 IS 4 SP 975 OP 980 DO https://doi.org/10.1099/0022-1317-64-4-975 PB Microbiology Society, SN 1465-2099, AB SUMMARY Using immune electron microscopy (IEM), low-level cross-reactions could be demonstrated between the surface antigens of hepatitis B and woodchuck hepatitis. However, immune complex formation was greatly enhanced by pre-exposure of the antigens to 0.5% deoxycholate. Cross-reaction between the core antigens and e antigens of both viruses was also confirmed by IEM as well as radioimmunassay. It appears that the woodchuck sera used in this study may well contain an anti-immunoglobulin akin to rheumatoid factor., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-4-975