1887

Abstract

SUMMARY

Using immune electron microscopy (IEM), low-level cross-reactions could be demonstrated between the surface antigens of hepatitis B and woodchuck hepatitis. However, immune complex formation was greatly enhanced by pre-exposure of the antigens to 0.5% deoxycholate. Cross-reaction between the core antigens and e antigens of both viruses was also confirmed by IEM as well as radioimmunassay. It appears that the woodchuck sera used in this study may well contain an anti-immunoglobulin akin to rheumatoid factor.

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/content/journal/jgv/10.1099/0022-1317-64-4-975
1983-04-01
2024-04-25
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References

  1. Feitelson M. A., Marion P. L., Robinson W. S. 1981; Antigenic and structural relationships of the surface antigens of hepatitis B virus, ground squirrel hepatitis virus and woodchuck hepatitis virus. Journal of Virology 39:447–454
    [Google Scholar]
  2. Galibert F., Chen T. N., Mandart E. 1981; Localization and nucleotide sequence of the gene coding for the woodchuck hepatitis virus surface antigen: comparison with the gene coding for the human hepatitis B virus surface antigen. Proceedings of the National Academy of Sciences, U. S. A 78:5315–5319
    [Google Scholar]
  3. Marion P. L., Oshiro L. S., Regnery D. C., Scullard G. H., Robinson W. S. 1980; A virus in Beechey ground squirrels that is related to hepatitis B virus of humans. Proceedings of the National Academy of Sciences, U. S. A 77:2941–2945
    [Google Scholar]
  4. Mason W. S., Seal G., Summers J. 1980; Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. Journal of Virology 36:829–836
    [Google Scholar]
  5. Millman I., Halbherr T., Simmons H. 1982; Immunological cross-reactivities of woodchuck and hepatitis B viral antigens. Infection and Immunity 35:752–757
    [Google Scholar]
  6. Stannard L. M., Hodgkiss M. 1979; Morphological irregularities in Dane particle cores. Journal of General Virology 45:509–514
    [Google Scholar]
  7. Stannard L. M., Almeida J. D., Tedder R. S. 1980; The role of rheumatoid factor in an electron microscope study of hepatitis B antigens. Journal of Medical Virology 6:153–164
    [Google Scholar]
  8. Stannard L. M., Lennon M., Hodgkiss M., Smuts H. 1982; An electron microscopic demonstration of immune complexes of hepatitis B e-antigen using colloidal gold as a marker. Journal of Medical Virology 9:165–175
    [Google Scholar]
  9. Summers J., Smolec J. M., Snyder R. 1978; A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proceedings of the National Academy of Sciences, U. S. A 75:4533–4537
    [Google Scholar]
  10. Werner B. G., Smolec J. M., Snyder R., Summers J. 1979; Serological relationship of woodchuck hepatitis virus to human hepatitis B virus. Journal of Virology 32:314–322
    [Google Scholar]
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