@article{mbs:/content/journal/jgv/10.1099/0022-1317-64-4-805, author = "Mathur, Asha and Arora, Kamlesh L. and Chaturvedi, U. C.", title = "Host Defence Mechanisms Against Japanese Encephalitis Virus Infection in Mice", journal= "Journal of General Virology", year = "1983", volume = "64", number = "4", pages = "805-811", doi = "https://doi.org/10.1099/0022-1317-64-4-805", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-4-805", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "IgM antibodies", keywords = "CMI", keywords = "immune protection", keywords = "JEV", abstract = "SUMMARY The role of antibody and cell-mediated immunity in the resistance to Japanese encephalitis virus (JEV) infection was studied in adult mice. Passively transferred antibodies obtained up to 2 weeks after primary infection protected the recipient mice against a challenge infection with JEV. Antibody obtained at 4 or 5 weeks failed to protect despite the presence of high titres of neutralizing antibody. Protection was abrogated by pretreatment of the early serum with 2-mercaptoethanol to remove IgM. Similarly, adoptive transfer of immune spleen cells obtained up to 2 weeks after immunization provided protection. The protective effect was abolished by pretreatment of the immune spleen cells with anti-Thy 1.2 antiserum and complement. These findings suggest a role of T lymphocytes and IgM antibody in recovery from JEV infection.", }