1887

Abstract

SUMMARY

A rat tumour induced by cells transformed with the sheared DNA of herpes simplex virus (HSV) type 1 HFEM α (RE2A) was injected with the intertypic virus HSV-2 HG52 1. Separate plaques, isolated from cocultivation of excised tumour tissue with susceptible cells, yielded virus the DNA of which had the restriction enzyme profile either of the injected HSV-2 virus or that of the HSV-1 virus, originally used to transform the cells. No evidence of recombination was detected. In Hooded Lister rats, HSV may have the ability to remain in a latent or non-replicating state in fibroblasts.

Keyword(s): HSV , latency and superinfection
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/content/journal/jgv/10.1099/0022-1317-64-3-755
1983-03-01
2022-10-07
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