@article{mbs:/content/journal/jgv/10.1099/0022-1317-64-3-707, author = "Jay, Francis T. and Dawood, Magdy R. and Friedman, Robert M.", title = "Interferon Induces the Production of Membrane Protein-deficient and Infectivity-defective Vesicular Stomatitis Virions through Interference in the Virion Assembly Process", journal= "Journal of General Virology", year = "1983", volume = "64", number = "3", pages = "707-712", doi = "https://doi.org/10.1099/0022-1317-64-3-707", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-3-707", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "proteins", keywords = "vesicular stomatitis virus", keywords = "interferon", abstract = "SUMMARY The reduced rate of synthesis, maturation and degradation as well as the level of accumulation of the intracellular virus proteins in VSV-infected cells may account for the overall reduction (less than 10-fold) of progeny virion yield due to interferon (IFN); however, the deficiency of the virions proteins, G and M, which apparently caused a drastic loss of infectivity of these progeny virions (about 1000-fold) cannot be easily explained, because the concentrations of G and M proteins relative to other virus proteins were not reduced in the cell. In fact, intracellular M protein was significantly increased. Moreover, the virus proteins in IFN-treated and control cells were synthesized and accumulated in large excess of the amount incorporated into the released virions. The reduction in the intracellular activity of GlcNac-P-P-Dol transferase did not appear to play a direct role in the antiviral mechanism in this system. Our results, however, do suggest that the deficiency of G and M proteins in the virion is related to specific inhibition of the incorporation of either or both of these proteins in the virus assembly process.", }