1887

Abstract

Summary

Two systems utilizing extracts derived from nuclei of adenovirus-infected cells which synthesize adenovirus DNA were analysed for indications of ADP-ribosylation of virus proteins. On incubation with [P]NAD or [C]NAD, modification of the adenovirus T antigen could be demonstrated in one of these systems. ADP-ribosylation of adenovirus core proteins V and VII could also be demonstrated with both nuclear extracts. However, using 3-aminobenzamide, a specific inhibitor of poly (ADP-ribose) polymerase, there was no evidence either or that ADP-ribosylation played a critical role in the replication process.

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/content/journal/jgv/10.1099/0022-1317-64-2-477
1983-02-01
2019-10-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-2-477
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