1887

Abstract

SUMMARY

Two systems utilizing extracts derived from nuclei of adenovirus-infected cells which synthesize adenovirus DNA were analysed for indications of ADP-ribosylation of virus proteins. On incubation with [P]NAD or [C]NAD, modification of the adenovirus T antigen could be demonstrated in one of these systems. ADP-ribosylation of adenovirus core proteins V and VII could also be demonstrated with both nuclear extracts. However, using 3-aminobenzamide, a specific inhibitor of poly (ADP-ribose) polymerase, there was no evidence either or that ADP-ribosylation played a critical role in the replication process.

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1983-02-01
2021-10-27
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References

  1. Adamietz P., Bredehorst R., Hilz H. 1978; ADP-ribosylated histone HI from HeLa cell cultures – fundamental differences to (ADP-ribose),histone HI conjugates formed in vitro. European Journal of Biochemistry 91:317–326
    [Google Scholar]
  2. Burzio L. O., Koide S. S., Puigdomenech P., Ruiz-Carillo A. 1980; ADP-ribosylation of rat liver HI and nucleosomal core histones. In Novel ADP-ribosylation of Regulatory Enzymes and Proteins vol 6: pp 345–353 Edited by Smulson M. E., Sugimura T. New York: Elsevier/North-Holland;
    [Google Scholar]
  3. Challberg M. D., Kelly T. J. 1979; Adenovirus DNA replication in vitro. Proceedings of the National Academy of Sciences of the United States of America 76:655–659
    [Google Scholar]
  4. Creissen D., Shall S. 1982; Regulation of DNA ligase activity by poly(ADP-ribose). Nature, London 296:271–272
    [Google Scholar]
  5. Durkacz B. W., Omidiji O., Gray D. A., Shall S. 1980; (ADP-ribose) participates in DNA excision repair. Nature, London 283:593–596
    [Google Scholar]
  6. Durkacz B. W., Irwin I., Shall S. 1981a; The effect of inhibition of (ADP-ribose)n biosynthesis on DNA repair assayed by the nucleoid technique. European Journal of Biochemistry 121:65–69
    [Google Scholar]
  7. Durkacz B. W., Irwin J., Shall S. 1981b; Inhibition of (ADP-ribosc) biosynthesis retards DNA repair but does not inhibit DNA repair synthesis. Biochemical and Biophysical Research Communications 101:1433–1441
    [Google Scholar]
  8. Edwards M. J., Taylor A. M. R. 1980; Unusual levels of (ADP-ribose) and DNA synthesis in ataxia telangiectasia cells following γ-ray irradiation. Nature, London 287:745–747
    [Google Scholar]
  9. Goding C. R. 1982; Adenovirus DNA structure and replication. Ph. D thesis C. N. A. A. London;
    [Google Scholar]
  10. Goldman N., Brown M., Khoury G. 1981; Modification of SV40 T antigen by poly ADP-ribosylation. Cell 24:567–572
    [Google Scholar]
  11. Hilz H., Stone P. 1976; Poly(ADP-ribose). Reviews of Physiology, Biochemistry and Pharmacology 76:1–58
    [Google Scholar]
  12. Jongstra-bilen J., Ittel M. E., Jongstra J., Mandel P. 1981; Similarities in the molecular weight of poly(ADPR) polymerase from different tissues and species. Abstracts of European Workshop on ADP-ribosyl transferase University of Sussex;
    [Google Scholar]
  13. Jump D. B., Butt T. R., Smulson M. 1980; Reconstitution of HeLa cell poly(adenosine diphosphate ribose) polymerase with purified oligonucleosomal chromatin. Biochemistry 19:1031–1037
    [Google Scholar]
  14. Kawaichi M., Ueda K., Hayashi O. 1980; Initiation of poly(ADP-ribosyl) histone synthesis by poly(ADP-ribose) synthetase. Journal of Biological Chemistry 255:816–819
    [Google Scholar]
  15. Kawaichi M., Ueda K., Hayashi O. 1981; Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Journal of Biological Chemistry 256:9483–9489
    [Google Scholar]
  16. Levinson A. D., Levine A. J. 1977; The isolation and identification of the adenovirus group C tumour antigens. Virology 76:1–12
    [Google Scholar]
  17. Lichy J. H., Horowitz M. S., Hurwitz J. 1981; Formation of a covalent complex between the 80000-dalton terminal protein and 5′-dCMP in vitro. Proceedings of the National Academy of Sciences of the United States of America 78:2678–2682
    [Google Scholar]
  18. Ohgushi H., Yoshihara K., Kamiya T. 1980; Bovine thymus poly(adenosine diphosphate ribose) polymerase - physical properties on binding to DNA. Journal of Biological Chemistry 255:6205–6211
    [Google Scholar]
  19. Oikawa A., Tohda H., Kanai M., Miwa M., Sugimura T. 1980; Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. Biochemical and Biophysical Research Communications 97:1311–1316
    [Google Scholar]
  20. Petzold S. J., Booth B. A., Leimbach G. A., Berger N. A. 1981; Purification and properties of poly(ADP-ribose) polymerase from lamb thymus. Biochemistry 20:7075–7081
    [Google Scholar]
  21. Pincus P., Robertson W., Rekosh D. 1981; Characterization of the effect of aphidicolin on adenovirus DNA replication:evidence in support of a protein primer model of initiation. Nucleic Acids Research 9:4919–4938
    [Google Scholar]
  22. Poirier G. G., De murcia G., Jongstra-bilen J., Niedergang C., Mandel P. 1982; Poly(ADP-riboSyl)ation of polynucleosomes causes relaxation of chromatin structure. Proceedings of the National Academy of Sciences of the United States of America 79:3423–3427
    [Google Scholar]
  23. Purnell M. R., Whish W. J. D. 1980; Novel inhibitors or poly(ADP-ribose) synthetase. Biochemical Journal 185:775–777
    [Google Scholar]
  24. Rekosh D. M. K., Russell W. C., Bellett A. J. D., Robinson A. J. 1977; Identification of a protein linked to the ends of adenovirus DNA. Cell 11:283–295
    [Google Scholar]
  25. Russell W. C., Blair G. E. 1977; Polypeptide phosphorylation in adenovirus-infected cells. Journal of General Virology 34:19–35
    [Google Scholar]
  26. Russell W. C., Precious B. 1982; Nucleic acid-binding properties of adenovirus structural polypeptides. Journal of General Virology 63:69–79
    [Google Scholar]
  27. Russell W. C., Skehel J. J. 1972; The polypeptides of adenovirus infected cells. Journal of General Virology 15:45–57
    [Google Scholar]
  28. Russell W. C., Laver W. G., Sanderson P. I. 1968; Internal components of adenovirus. Nature, London 219:1127–1130
    [Google Scholar]
  29. Russell W. C., Mcintosh K., Skehel J. J. 1971; The preparation and properties of adenovirus cores. Journal of General Virology 11:35–46
    [Google Scholar]
  30. Russell W. C., Patel G., Precious B., Sharp I., Gardner P. S. 1981; Monoclonal antibodies against adenovirus type 5: preparation and preliminary characterization. Journal of General Virology 56:393–408
    [Google Scholar]
  31. Shaw C. H., Russell W. C., Rekosh D. M. K. 1979; Association of adenovirus early proteins with a nuclear fraction that synthesises DNA in vitro. Virology 92:436–448
    [Google Scholar]
  32. Sims J. L., Sikorski G. W., Catino D. M., Berger S. J., Berger N. A. 1982; Poly(adenosinedisphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes. Biochemistry 21:1813–1821
    [Google Scholar]
  33. Stone P. R., Lorimer W. S., Kidwell W. R. 1977; Properties of the complex between histone HI and poly(ADP ribose) synthesised in HeLa cell nuclei. European Journal of Biochemistry 81:9–18
    [Google Scholar]
  34. Ueda K., Omachi A., Kawaichi M., Hayaishi O. 1975; Natural occurrence of poly(ADP-ribosyl) histones in rat liver. Proceedings of the National Academy of Sciences of the United States of America 72:205–209
    [Google Scholar]
  35. Williams J. F. 1973; Oncogenic transformation of hamster embryo cells in vitro by adenovirus type 5. Nature, London 243:162–163
    [Google Scholar]
  36. Yoshihara K., Hashida T., Tanaka Y., Matsunami N., Yamaguchi A., Kamiya T. 1981; Mode of enzyme-bound poly(ADP-ribose) synthesis and histone modification by reconstituted poly(ADP-ribose) polymerase-DNA-cellulose complex. Journal of Biological Chemistry 256:3471–3478
    [Google Scholar]
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