%0 Journal Article %A Sethi, K.K. %A Omata, Y. %A Schneweis, K. E. %T Protection of Mice from Fatal Herpes Simplex Virus Type 1 Infection by Adoptive Transfer of Cloned Virus-specific and H-2-restricted Cytotoxic T Lymphocytes %D 1983 %J Journal of General Virology, %V 64 %N 2 %P 443-447 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-64-2-443 %K protection %K HSV-1 %K cytotoxic T lymphocytes %I Microbiology Society, %X SUMMARY A cloned culture of secondary anti-herpes simplex virus (anti-HSV) cytotoxic T lymphocytes (CTL) generated in vitro when adoptively transferred to intact or cyclophosphamide (CP) pretreated syngeneic mice protected the recipients from death following intraperitoneal infection with HSV-1. This in vivo protective effect conferred by anti-HSV CTL was virus-specific and H-2K/D-restricted. Twenty-four h after HSV-1 infection of BALB/c mice (intact or CP-pretreated) relatively high levels of serum interferon-γ were observed in the recipients of syngeneic anti-HSV CTL and this event may explain, at least in part, the CTL-mediated protective effect. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-2-443