1887

Abstract

Summary

A cloned culture of secondary anti-herpes simplex virus (anti-HSV) cytotoxic T lymphocytes (CTL) generated when adoptively transferred to intact or cyclophosphamide (CP) pretreated syngeneic mice protected the recipients from death following intraperitoneal infection with HSV-1. This protective effect conferred by anti-HSV CTL was virus-specific and H-2K/D-restricted. Twenty-four h after HSV-1 infection of BALB/c mice (intact or CP-pretreated) relatively high levels of serum interferon-γ were observed in the recipients of syngeneic anti-HSV CTL and this event may explain, at least in part, the CTL-mediated protective effect.

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/content/journal/jgv/10.1099/0022-1317-64-2-443
1983-02-01
2019-09-19
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-2-443
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