1887

Abstract

SUMMARY

With the aid of 11 neutralizing monoclonal antibodies which were investigated in four different neutralization tests, evidence was provided that several unrelated epitopes for neutralizing antibodies exist on the surface of poliovirus type 1. All monoclonal antibodies were able to neutralize poliovirus infectivity prior to and after virus adsorption to host cells. The quantitative enzyme-linked immunosorbent assay is introduced as a second independent system for the determination of antibody specificity. Antibodies could be divided into four groups according to their reaction patterns.

Keyword(s): ELISA , epitopes , neutralization and poliovirus
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/content/journal/jgv/10.1099/0022-1317-64-12-2809
1983-12-01
2022-08-17
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