@article{mbs:/content/journal/jgv/10.1099/0022-1317-64-11-2505, author = "Rubenstein, Richard and Price, Richard W.", title = "Preservation of Catecholamine Uptake and Release in Herpes Simplex Virus Type 1-infected PC12 Cells", journal= "Journal of General Virology", year = "1983", volume = "64", number = "11", pages = "2505-2509", doi = "https://doi.org/10.1099/0022-1317-64-11-2505", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-11-2505", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "neurons", keywords = "HSV-1", keywords = "catecholamines", abstract = "SUMMARY The PC12 cell line, which is derived from a rat pheochromocytoma and possesses a number of ‘differentiated’ neuronal properties, was used to characterize the effect of herpes simplex virus type 1 (HSV-1) infection on the uptake and release of catecholamines. Both the uptake of [3H]norepinephrine and the content and K+-induced release of endogenous catecholamines were remarkably preserved during the course of productive infection. HSV-1 infection is thus selective in its effects on the host cell and certain specialized functional properties may be retained in the face of otherwise profound metabolic alterations.", }