1887

Abstract

SUMMARY

The PC12 cell line, which is derived from a rat pheochromocytoma and possesses a number of ‘differentiated’ neuronal properties, was used to characterize the effect of herpes simplex virus type 1 (HSV-1) infection on the uptake and release of catecholamines. Both the uptake of [H]norepinephrine and the content and K-induced release of endogenous catecholamines were remarkably preserved during the course of productive infection. HSV-1 infection is thus selective in its effects on the host cell and certain specialized functional properties may be retained in the face of otherwise profound metabolic alterations.

Keyword(s): catecholamines , HSV-1 and neurons
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/content/journal/jgv/10.1099/0022-1317-64-11-2505
1983-11-01
2022-06-29
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