1887

Abstract

Summary

The distribution of measles virus antigens in an auto-degenerating persistently infected human cell line (AVAl/MV) was examined by a direct fluorescent antibody technique. The appearance of virus antigens in cell nuclei increased with time and passage number, and correlated to a decrease in cell replication rates and increases in cellular pathology and mortality. Nuclei which had been invaded by virus antigens were frequently swollen and the cells tended to have round rather than cuboidal morphologies. The correlation between cell degeneration and viral nuclear invasion in this system suggests that quantification of viral nuclear invasion may be useful as a pathological marker of relative cell morbidity in persistent measles virus infections.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-64-10-2335
1983-10-01
2019-10-17
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-10-2335
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error