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Volume 64, Issue 10

Strain Difference in Immune Response of the Rat to NRK Cells Infected with Spleen Focus-forming Virus of the Friend Leukaemia Virus Complex Free

Abstract

SUMMARY

Five rat strains were studied for immune responsiveness to SFFV-NRK, a normal rat kidney cell line non-productively infected with spleen focus-forming virus (SFFV) of the Friend leukaemia virus (FLV) complex. Antisera from ACI, JAR, Fischer and SD strains precipitated SFFV-specific gene product, gp55, whereas those from LEW did not. In the cross of Fischer × LEW, immune responsiveness to gp55 was controlled by a single or a few dominant genes. The immune responsiveness was neither related to the susceptibility to FLV infection, nor to the amount of SFFV-related RNA in spleen cells. Unresponsiveness of LEW rats to gp55 was not absolute; when LEW rats were immunized with FLV preparations from infected mice or xenotropic virus-infected NRK cells, they produced antibody that could precipitate gp55.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Friend leukaemia virus , genetics , gp55 and immune response
© Journal of General Virology 1983
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1983-10-01
2024-04-23
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Strain Difference in Immune Response of the Rat to NRK Cells Infected with Spleen Focus-forming Virus of the Friend Leukaemia Virus Complex
J. Gen. Virol. 64, 2169 (1983); https://doi.org/10.1099/0022-1317-64-10-2169
/content/journal/jgv/10.1099/0022-1317-64-10-2169
/content/journal/jgv/10.1099/0022-1317-64-10-2169
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