1887

Abstract

SUMMARY

We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (D) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation.

Keyword(s): homology , HSV , inversion and recombination
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/content/journal/jgv/10.1099/0022-1317-64-1-247
1983-01-01
2021-10-21
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