Involvement of Glycolipids in Myxovirus-induced Membrane Fusion (Haemolysis) Free

Abstract

SUMMARY

Myxoviruses (influenza viruses and paramyxoviruses) penetrate their host cells by fusion of viral and cellular membranes. During this process, virus envelopes react with galactose-terminating glycolipids of cellular membranes. This was suggested by experiments showing the ability of these lipids to inhibit fusion (as measured by haemolysis) when reacted with the viruses, and to enhance it when added as enrichment to erythrocytes.

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1983-01-01
2024-03-29
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References

  1. Bächi T., Deas J. E., Howe C. 1977; Virus-erythrocytes interactions. In Cell Surface Reviews pp 83–127 Edited by Poste G., Nicolson G. L. Amsterdam: North-Holland;
    [Google Scholar]
  2. Chucholowius H.-W., Rott R. 1972; A new method for purification of myxoviruses by zonal centrifugation with two different sucrose density gradients. Proceedings of the Society for Experimental Biology and Medicine 140:245–247
    [Google Scholar]
  3. Compans R. W., Klenk H.-D. 1979; Viral membranes. In Comprehensive Virology pp 293–407 Edited by Fraenkel-Conrat H., Wagner R. R. New York: Plenum Press;
    [Google Scholar]
  4. Dimmock N. J. 1982; Initial stages in infection with animal viruses. Journal of General Virology 59:1–22
    [Google Scholar]
  5. Dourmashkin R. R., Tyrrell D. A. 1974; Electron microscopic observation on the entry of influenza virus into susceptible cells. Journal of General Virology 24:129–141
    [Google Scholar]
  6. Gething M. J., White J. M., Waterfield M. D. 1978; Purification of the fusion protein of Sendai virus. Analysis of the NH2-terminal sequence generated during precursor activation. Proceedings of the National Academy of Sciences of the United States of America 75:2737–2740
    [Google Scholar]
  7. Haywood A. M. 1974; Fusion of Sendai virus with model membranes. Journal of Molecular Biology 87:625–628
    [Google Scholar]
  8. Helenius A., Kartenbeck J., Simons K., Fries E. 1980; On the entry of Semliki Forest virus into BHK-21 cells. Journal of Cell Biology 84:404–420
    [Google Scholar]
  9. Huang R. T. C. 1978; Cell adhesion mediated by glycolipids. Nature, London 276:624–626
    [Google Scholar]
  10. Huang R. T. C., Rott R., Wahn K., Klenk H.-D., Kohama T. 1980a; The function of the neuraminidase in membrane fusion induced by myxoviruses. Virology 107:313–319
    [Google Scholar]
  11. Huang R. T. C., Wahn K., Klenk H.-D., Rott R. 1980b; Fusion between cell membrane and liposomes containing the glycoproteins of influenza viruses. Virology 104:294–302
    [Google Scholar]
  12. Huang R. T. C., Rott R., Klenk H.-D. 1981a; Influenza viruses cause hemolysis and fusion of cells. Virology 110:243–247
    [Google Scholar]
  13. Huang R. T. C., Wahn K., Schmidt M. F. G., Rott R. 1981b; Productive infection of chick embryo cells by influenza viruses tightly bound on substratum. Medical Microbiology and Immunology 170:91–98
    [Google Scholar]
  14. Klenk H.-D., Rott R., Orlich M., Blodorn J. 1975; Activation of influenza viruses by trypsin treatment. Virology 68:429–439
    [Google Scholar]
  15. Maeda T., Ohnishi S. I. 1980; Activation of influenza viruses by acidic media causes hemolysis and fusion of erythrocytes. FEBS Letters 122:283–287
    [Google Scholar]
  16. Maeda T., Kawasaki K., Ohnishi S. I. 1981; Interaction of influenza virus hemagglutinin with target membrane lipids is a key step in virus-induced hemolysis and fusion at pH 5.2. Proceedings of the National Academy of Sciences of the United States of America 78:4133–4138
    [Google Scholar]
  17. Miller D. K., Lenard J. 1981; Antihistamine, local anaesthetics and other amines as antiviral agents. Proceedings of the National Academy of Sciences of the United States of America 78:3605–3609
    [Google Scholar]
  18. Richardson C. D., Scheid A., Choppin P. W. 1980; Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequence similar to those at the N-termini of the F1 or HA2 viral polypeptides. Virology 105:205–222
    [Google Scholar]
  19. Rott R., Klenk H.-D. 1977; Structure and assembly of viral envelopes. In Cell Surface Reviews pp 47–81 Edited by Poste G., Nicolson G. L. Amsterdam: North-Holland;
    [Google Scholar]
  20. Scheid A., Caliguri L. A., Compans R. W., Choppin P. W. 1972; Isolation of paramyxovirus glycoproteins. Association of both hemagglutinin and neuraminidase activities with the large SV 5 glycoproteins. Virology 50:640–652
    [Google Scholar]
  21. Väänänen P., Kääriäinen L. 1979; Haemolysis by two alphaviruses. Journal of General Virology 43:593–601
    [Google Scholar]
  22. White J., Matlin K., Helenius A. 1981; Cell fusion by Semliki Forest, influenza and vesicular stomatitis virus. Journal of Cell Biology 89:674–679
    [Google Scholar]
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