%0 Journal Article %A Yamamoto, Nobuto %A Gemski, P. %A Baron, L. S. %T Genetic Studies of Hybrids Between Coliphage ϕ80 and Salmonella Phage P22 %D 1983 %J Journal of General Virology, %V 64 %N 1 %P 199-205 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-64-1-199 %K P22 %K phage-phage recombination %K ϕ80 %K genetic homology %I Microbiology Society, %X SUMMARY Hybrids between Escherichia coli phage ϕ80 and Salmonella typhimurium phage P22 were isolated after superinfection by P22 of a smooth E. coli-S. typhimurium hybrid lysogenic for ϕ80. These hybrid phages, designated ϕ80immP22 and ϕ80immP22dis, possessed the ϕ80 protein coat and tail genes. The ϕ80immP22 hybrids acquired the immunity (immC) region of P22 and some adjacent P22 genes, but E. coli-S. typhimurium strains lysogenic for ϕ80immP22 hybrids remained sensitive to P22. The ϕ80immP22dis hybrids, found ten times more frequently than the ϕ80immP22 hybrids, contained a more extensive portion of the P22 genome which encompassed the immI as well as the immC region of P22. Therefore, the ϕ80immP22dis hybrids conferred on their hosts immunity to P22 infection. Further analyses have revealed that the ϕ80immP22dis hybrids carry the P22 attachment region and either P22 tail gene 9 or antigen conversion gene al, but not both of these genes. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-1-199