@article{mbs:/content/journal/jgv/10.1099/0022-1317-63-2-505, author = "Tovey, Michael G. and Gresser, Ion and Rochette-Egly, Cécile and Begon-Lours-Guymarho, Jacqueline and Bandu, Marie-Thérèse and Maury, Chantal", title = "Indomethacin and Aspirin Do Not Inhibit the Antiviral or Anti-proliferative Actions of Interferon", journal= "Journal of General Virology", year = "1982", volume = "63", number = "2", pages = "505-508", doi = "https://doi.org/10.1099/0022-1317-63-2-505", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-63-2-505", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "interferon", keywords = "indomethacin", keywords = "aspirin", abstract = "Summary Neither indomethacin nor aspirin, at concentrations which inhibited the formation of prostaglandins and prevented the interferon-induced increase in the intracellular concentration of cyclic GMP, had any significant effect on the development of the interferon-induced antiviral state either in mouse L1210 cells challenged with vesicular stomatitis virus or in mice infected with encephalomyocarditis virus. Furthermore, neither drug had any significant effect on the interferon-induced inhibition of cell multiplication in cultures of mouse leukaemia L1210 cells. The differences in the effects of these cyclo-oxygenase inhibitors on different interferon effects may provide some insight into the different pathways of interferon action.", }