1887

Abstract

Summary

Neither indomethacin nor aspirin, at concentrations which inhibited the formation of prostaglandins and prevented the interferon-induced increase in the intracellular concentration of cyclic GMP, had any significant effect on the development of the interferon-induced antiviral state either in mouse L1210 cells challenged with vesicular stomatitis virus or in mice infected with encephalomyocarditis virus. Furthermore, neither drug had any significant effect on the interferon-induced inhibition of cell multiplication in cultures of mouse leukaemia L1210 cells. The differences in the effects of these cyclo-oxygenase inhibitors on different interferon effects may provide some insight into the different pathways of interferon action.

Keyword(s): aspirin , indomethacin and interferon
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/content/journal/jgv/10.1099/0022-1317-63-2-505
1982-12-01
2021-10-17
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References

  1. Chandrabose K. A., Cuatrecasas P., Pottathil R., Lang D. J. 1981; Interferon resistant cell line lacks fatty acid cyclo-oxygenase activity. Science 212:329–331
    [Google Scholar]
  2. Glass D. B., Gerrard J. M., Townsend D., Carr D. W., White J. G., Goldberg N. D. 1977; The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation. Journal of Cyclic Nucleotide Research 3:37–44
    [Google Scholar]
  3. Pottathil R., Chandrabose K. A., Cuatrecasas P., Lang D. J. 1980; Establishment of the interferon- mediated antiviral state: role of fatty acid cyclo-oxygenase. Proceedings of the National Academy of Sciences of the United States of America 77:5437–5440
    [Google Scholar]
  4. Rochette C., Castagna M. 1977; A simultaneous protein-binding assay for adenosine 3'-5'-monophosphate and guanosine 3',5'-monophosphate in biological materials. Biochemical and Biophysical Research Communications 74:1287–1296
    [Google Scholar]
  5. Scott G. M., Secher D. S., Flowers D., Bate J., Cantell K., Tyrrell D. A. J. 1981; Toxicity of interferon. British Medical Journal 282:1345–1348
    [Google Scholar]
  6. Tovev M. G., Rochette-Egly C. 1981; Rapid increase in guanosine 3',5'-cyclic-monophosphate in interferon treated mouse leukemia LI 210 cells: relationship to the development of the antiviral state and inhibition of cell multiplication. Virology 115:272–281
    [Google Scholar]
  7. Tovey M. G., Begon-Lours J., Gresser I. 1974; A method for the large scale production of potent interferon preparations. Proceedings of the Society for Experimental Biology and Medicine 146:809–815
    [Google Scholar]
  8. Tovey M. G., Rochette-Egly C., Castagna M. 1979; Effect of interferon on concentrations of cyclic nucleotides in cultured cells. Proceedings of the National Academy of Sciences of the United States ofAmerica 76:3890–3893
    [Google Scholar]
  9. Tovey M. G., Rochette-Egly C., Kolb J. P. 1982; Interferon enhancement of natural killer cell cytotoxicity: role of cyclic nucleotides. Journal of Interferon Research (in press)
    [Google Scholar]
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