1887

Abstract

Summary

Dissemination of herpes simplex virus (HSV) in nude mice after intracutaneous inoculation in the midflank, and the effect of passively administered antibody on the course of infection were investigated. In untreated infected mice the skin lesions developed rapidly and HSV could first be recovered from the homogenate of the dorsal root ganglia on day 3 after infection, from the spinal cord on day 7 and from the brain on day 11. HSV could not be recovered from the blood, spleen or liver. In mice passively immunized with human gamma globulin, development of the skin lesions was rather slow and HSV could not be recovered from the homogenate of the dorsal root ganglia until day 16. From the results of explant culture of the ganglia, HSV was found to have reached the ganglia as early as 48 h after infection, even in mice administered human gamma globulin. The protective action of antibody seems to originate from the inhibition of virus growth not only at the inoculation site but also in the dorsal root ganglia.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-63-2-475
1982-12-01
2021-10-23
Loading full text...

Full text loading...

/deliver/fulltext/jgv/63/2/JV0630020475.html?itemId=/content/journal/jgv/10.1099/0022-1317-63-2-475&mimeType=html&fmt=ahah

References

  1. Cook M. L., Stevens J. G. 1973; Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra- axonal transport of infection. Infection and Immunity 7:272–288
    [Google Scholar]
  2. Davis W. B., Taylor J. A., Oakes J. E. 1979; Ocular infection with herpes simplex virus type 1: prevention of acute herpetic encephalitis by systemic administration of virus-specific antibody. Journal of Infectious Diseases 140:534–540
    [Google Scholar]
  3. Hayashida I., Nagafuchi S., Hayashi Y., Kino Y., Mori R., Oda H., Ohtomo N., Tashiro A. 1982; Mechanism of antibody mediated protection against herpes simplex virus infection in athymic nude mice: requirement of Fc portion of antibody. Microbiology and Immunology 26:497–509
    [Google Scholar]
  4. Hill T., Field H. J., Roome A. P. C. 1972; Intra-axonal location of herpes simplex virus particles. Journal of General Virology 15:253–255
    [Google Scholar]
  5. Johnson R. T. 1963; The pathogenesis of herpes virus encephalitis. I. Virus pathways to the nervous system of suckling mice demonstrated by fluorescent antibody staining. Journalof Experimental Medicine 119:343–365
    [Google Scholar]
  6. Kapoor A. K., Nash A. A., Wildy P., Phelan J., McLean C. S., Field H. J. 1982; Pathogenesis of herpes simplex virus in congenitally athymic mice: the relative roles of cell-mediated and humoral immunity. Journal of General Virology 60:225–233
    [Google Scholar]
  7. Knotts F. B., Cook M. L., Stevens J. G. 1974; Pathogenesis of herpes encephalitis in mice after ophthalmic inoculation. Journal of Infectious Diseases 130:16–27
    [Google Scholar]
  8. McKendall R. R., Klassen T., Baringer J. R. 1979; Host defenses in herpes simplex infections of the nervous system: effect of antibody on disease and viral spread. Infection and Immunity 23:305–311
    [Google Scholar]
  9. Nagafuchi S., Oda H., Mori R., Taniguchi T. 1979; Mechanism of acquired resistance to herpes simplex virus infection as studied in nude mice. Journal of General Virology 44:715–723
    [Google Scholar]
  10. Oakes J. E. 1975a; Invasion of the central nervous system by herpes simplex virus type 1 after subcutaneous inoculation of immunosuppressed mice. Journal of Infectious Diseases 131:51–57
    [Google Scholar]
  11. Oakes J. E. 1975b; Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection. Infection and Immunity 12:166–172
    [Google Scholar]
  12. Oakes J. E., Lausch R. N. 1981; Role of Fc fragments in antibody-mediated recovery from ocular and subcutaneous herpes simplex virus infection. Infection and Immunity 33:109–114
    [Google Scholar]
  13. Openshaw H., Asher L. V. S., Wohlenberg C., Sekizawa T., Notkins A. L. 1979; Acute and latent infection of sensory ganglia with herpes simplex virus: immune control and virus reactivation. Journal of General Virology 44:205–215
    [Google Scholar]
  14. Rager-Zisman B., Allison A. C. 1976; Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection. Journal of Immunology 116:35–40
    [Google Scholar]
  15. Renis H. E., Edison E. E., Mathews J., Gray L. E. 1976; Pathogenesis of herpes simplex virus type 1 and 2 in mice after various routes of inoculation. Infection and Immunity 14:571–578
    [Google Scholar]
  16. Sydiskis R., Schultz I. 1965; Herpes simplex skin infection in mice. Journal of Infectious Diseases 115:237–246
    [Google Scholar]
  17. Walz M. A., Yamamoto H., Notkins A. L. 1976; Immunological response restricts number of cells in sensory ganglia infected with herpes simplex virus. Nature, London 264:554–556
    [Google Scholar]
  18. Wildy P. 1967; The pathogenesis of herpes simplex virus to the central nervous system of the mouse. Journal of Hygiene 65:173–192
    [Google Scholar]
  19. Worthington M., Conliffe M. A., Baron S. 1980a; Mechanism of recovery from systemic herpes simplex virus infection. I. Comparative effectiveness of antibody and reconstitution of immune spleen cells on immunosuppressed mice. Journal of Infectious Diseases 142:163–174
    [Google Scholar]
  20. Worthington M., Conliffe M. A., Baron S. 1980b; Mechanism of recovery from systemic herpes simplex virus infection. II. Effectiveness of antibody reconstitution of nude and neonatally thymectomized mice. Proceedings of the Society for Experimental Biology and Medicine 165:462–468
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-63-2-475
Loading
/content/journal/jgv/10.1099/0022-1317-63-2-475
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error