Measles Virus Persistence in Human Lymphocytes: A Role for Virus-induced Interferon Free

Abstract

Summary

Because of the association of measles virus with persistent infections such as subacute sclerosing panencephalitis, and its possible involvement in multiple sclerosis, we have investigated the capacity of this virus to establish chronic infections in human peripheral blood lymphocytes (PBLs). We have demonstrated that a latent, persistent infection of human PBLs with measles virus results in low levels of infectious virus production in which large amounts of virus-induced interferon could be detected. Further, treatment of these silently infected cells with an anti-human leukocyte interferon serum results in a productive measles virus infection. The mechanism by which the anti-interferon serum shifts the virus-cell interaction from persistence to productive infection is discussed.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-63-2-351
1982-12-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/63/2/JV0630020351.html?itemId=/content/journal/jgv/10.1099/0022-1317-63-2-351&mimeType=html&fmt=ahah

References

  1. Bellini W. J., Trudgett A., McFarlin D. E. 1979; Purification of measles virus with preservation of infectivity and antigenicity. Journal of General Virology 43:633–639
    [Google Scholar]
  2. Berger S. L., Hitchcock M. J. M., Zoon K. C., Birkenmeier C. S., Friedman R. M., Chang E. M. 1980; Characterization of interferon messenger RNA synthesis in Namalwa cells. Journal of Biological Chemistry2552955–2961
    [Google Scholar]
  3. Epstein L. B. 1977; The effects of interferons on the immune responses in vitro and in vivo . In Interferons and Their Actions pp. 91–132 Edited by Stewart W. E. II Florida: CRC Press;
    [Google Scholar]
  4. Hasse A. T., Ventura P., Gibbs C. J., Tourtellotte W. W. 1981; Measles virus nucleotide sequences; detection by hybridization in situ . Science 212:672–674
    [Google Scholar]
  5. Horta-Barbosa L., Hamilton R., Wiggig B., Fucillo D. A., Sever J. 1971; Subacute sclerosing panencephalitis; isolation of suppressed measles virus from lymph node biopsies. Science 173:840–841
    [Google Scholar]
  6. Joseph B. S., Lampert P. W., Oldstone M. B. A. 1975; Replication and persistence of measles virus in defined subpopulations of human leukocytes. Journal of Virology 16:1638–1649
    [Google Scholar]
  7. Kato T., Minagawa T. 1981; Cellular source of interferon induced in human peripheral blood mononuclear leukocytes by mumps virus or by tumour cells persistently infected with mumps virus. Journal of General Virology 54:293–299
    [Google Scholar]
  8. Lucas C. J., Galama J. M. D., Ubels-Postma J. 1977; Measles virus-induced suppression of lymphocyte reactivity in vitro . Cellular Immunology 32:70–85
    [Google Scholar]
  9. Lucas C. J., Ubels-Postma I., Galama J. M. D., Rezee A. 1978a; Studies on the mechanism of measles virus induced suppression of lymphocyte functions in vitro. Lack of a role for interferon and monocytes. Cellular Immunology 37:448–458
    [Google Scholar]
  10. Lucas C. J., Ubels-Postma J. C., Rezee A., Galama J. M. D. 1978b; Activation of measles virus from silently infected human lymphocytes. Journal of Experimental Medicine 148:940–952
    [Google Scholar]
  11. Maheshwari R. K., Banerjee D. K., Waechter C. J., Olden K., Friedman R. M. 1980; Interferon treatment inhibits glycosylation of a viral protein. Nature, London 287:454–458
    [Google Scholar]
  12. Nagai Y., Ito Y., Hamaguchi M., Yoshida T., Matsumoto T. 1981; Relations of interferon production to the limited replication of Newcastle disease virus in L cells. Journal of General Virology 55:109–116
    [Google Scholar]
  13. Nowakowski M., Feldman J. D., Kano S., Bloom B. R. 1973; The production of vesicular stomatitis virus by antigen or mitogen-stimulated lymphocytes and continuous lymphoblastoid lines. Journal of Experimental Medicine 137:1042–1058
    [Google Scholar]
  14. Neighbour P. A., Bloom B. R. 1979; Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 76:476–480
    [Google Scholar]
  15. Neighbour P. A., Miller A. E., Bloom B. R. 1981; Interferon responses of leukocytes in multiple sclerosis. Neurology 31:561–566
    [Google Scholar]
  16. Rammohan K. W., McFarlin D. E., McFarland H. F. 1980; Chronic measles encephalitis in mice. Journal of Infectious Diseases 142:608–613
    [Google Scholar]
  17. Rammohan K. W., McFarland H. F., McFarlin D. E. 1981; Induction of subacute murine measles encephalitis by monoclonal antibody to virus haemagglutinin. Nature, London 290:588–589
    [Google Scholar]
  18. Sullivan J. L., Barry D. W., Lucas S. J., Albrecht P. 1975; Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes. Journal of Experimental Medicine 142:773–784
    [Google Scholar]
  19. Volckaert-Vervliet G., Billiau A. 1977; Induction of interferon in human lymphoblastoid cells by Sendai and measles virus. Journal of General Virology 37:199–203
    [Google Scholar]
  20. Volckaert-Vervliet G., Heremans M., De Ley R., Billiau A. 1978; Interferon induction and action in human lymphoblastoid cells infected with measles virus. Journal of General Virology 41:459–466
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-63-2-351
Loading
/content/journal/jgv/10.1099/0022-1317-63-2-351
Loading

Data & Media loading...

Most cited Most Cited RSS feed