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We have generated several variants of the human lymphoid cell line Namalwa which were characterized as high producers, non-producers and spontaneous producers of interferon (IFN). All of them were stable for more than 1 year, suggesting chromosomal inheritance of their mutations. We show the kinetics and quantity of IFN production following treatment with several inducers, including polyriboinosinic-polyribocytidylic acid [poly(rI).poly(rC)].
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