1887

Abstract

SUMMARY

Purified virus proteins from transformation-defective () mutants of Rous sarcoma virus PrA or PrB were trapped in human erythrocyte ghosts which, after resealing, were fusion-injected into hamster cells or rat cells. These cell lines are non-productively transformed by subgroup C Rous sarcoma virus. After fusion injection the hamster RBH cells released transforming subgroup C Rous sarcoma virus. No infectious virus could be rescued from rat cells. Since previous experiments have shown that fusion injection of the purified Rous sarcoma virus protein p 15 into hamster RBH cells caused cleavage of the precursor protein pr76 to form the virus group-specific antigen (gag) but did not induce infectious virus, we conclude that in addition to p 15 other virus proteins are required to induce virus rescue in hamster cells.

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/content/journal/jgv/10.1099/0022-1317-61-1-83
1982-07-01
2024-04-23
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