1887

Abstract

SUMMARY

Adult athymic Nu/Nu mice showed increased susceptibility to lethal infection with murine cytomegalovirus () when compared to their heterozygous T cell-competent Nu/+ littermates. However, the extent of this increase in susceptibility varied dramatically depending on the genetic background of the mice carrying the Nu/Nu gene. Genetically susceptible Balb/c ( ) mice showed a greater than 316-fold difference between the LD of Nu/Nu and Nu/+ littermates. In marked contrast, the genetically resistant CBA ( ) strain was characterized by only a 16-fold difference in resistance between Nu/Nu and Nu/+ mice, and furthermore, the athymic CBA Nu/Nu mice were no more susceptible than the T cell-competent Balb/c Nu/+ strain. These results together with previous observations strongly suggest that the ( )-associated resistance of the CBA strain is mediated by non-T cell-dependent early defence mechanisms.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-61-1-133
1982-07-01
2021-10-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/61/1/JV0610010133.html?itemId=/content/journal/jgv/10.1099/0022-1317-61-1-133&mimeType=html&fmt=ahah

References

  1. Bancroft G. J., Shellam G. R., Chalmer J. E. 1981; Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. Journal of Immunology 126:988–994
    [Google Scholar]
  2. Booss J., Wheelock E. F. 1975; Correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to concanavalin A. Proceedings of the Society for Experimental Biology and Medicine 149:433–446
    [Google Scholar]
  3. Chalmer J. E., Mackenzie J. S., Stanley N. F. 1977; Resistance to murine cytomegalovirus linked to the major histocompatibility complex of the mouse. Journal of General Virology 37:107–114
    [Google Scholar]
  4. Grundy (Chalmer) J. E., Mackenzie J. S., Stanley N. F. 1981; Influence of H-2 and non H-2 genes on resistance to murine cytomegalovirus infection. Infection and Immunity 32:277–286
    [Google Scholar]
  5. Grundy (Chalmer) J. E., Trapman J., Allan J. E., Shellam G. R., Melief C. J. M. 1982; Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes. Infection and Immunity (in press)
    [Google Scholar]
  6. Herberman R. B., Holden H. T. 1978; Natural cell-mediated immunity. Advances in Cancer Research 27:305–377
    [Google Scholar]
  7. Selgrade M. K., Ahmed A., Sell K. W., Gershwin M. E., Steinberg A. D. 1976; Effect of murine cytomegalovirus on the in vitro responses of T and B cells to mitogens. Journal of Immunology 116:1459–1465
    [Google Scholar]
  8. Starr S. E., Allison A. C. 1977; Role of T lymphocytes in recovery from murine cytomegalovirus infection. Infection and Immunity 17:458–462
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-61-1-133
Loading
/content/journal/jgv/10.1099/0022-1317-61-1-133
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error