Pathogenesis of Herpes Simplex Virus in B Cell-suppressed Mice: the Relative Roles of Cell-mediated and Humoral Immunity Free

Abstract

SUMMARY

B cell responses of Balb/c mice were suppressed using sheep anti-mouse IgM serum. At 4 weeks, both B cell-suppressed and normal littermates were infected in the ear pinna with herpes simplex virus type 1 (HSV-1). The B cell-suppressed mice failed to produce neutralizing herpes antibodies in their sera but had a normal cell-mediated immunity (CMI) response as measured by a delayed hypersensitivity skin test. Although the infection was eliminated from the ear in both B cell-suppressed and normal mice by day 10 after infection, there was an indication that B cell-suppressed mice had a more florid primary infection of the peripheral and central nervous system and also a higher incidence of a latent infection. These results support the hypothesis that antibody is important in restricting the spread of virus to the central nervous system, whereas CMI is important in clearing the primary infection in the ear pinna.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-61-1-127
1982-07-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/61/1/JV0610010127.html?itemId=/content/journal/jgv/10.1099/0022-1317-61-1-127&mimeType=html&fmt=ahah

References

  1. Burnet F. M., Lush D. 1939; Studies on experimental herpes infection in mice, using the chorioallantoic technique. Journal of Pathology and Bacteriology 49:241–259
    [Google Scholar]
  2. Field H. J., Bell S. E., Elion G. B., Nash A. A., Wildy P. 1979; Effect of acycloguanosine treatment on acute and latent herpes simplex infections in mice. Antimicrobial Agents and Chemjournalapy 15:554–561
    [Google Scholar]
  3. Friend P. S., Theofilopoulos A. N., Fidler J. M., Dixon F. J. 1981; B-cell suppression by anti-IgM antibody: humoral and cellular analyses. Cellular Immunology 61:405–415
    [Google Scholar]
  4. Gordon J. 1979; The B lymphocyte-deprived mouse as a tool in immunobiology. Journal of Immunological Methods 25:227–238
    [Google Scholar]
  5. Hill T. J., Field H. J., Blyth W. A. 1975; Acute and recurrent infection with herpes simplex in the mouse: a model for studying latency and recurrent disease. Journal of Generai Virology 28:341–353
    [Google Scholar]
  6. Kapoor A. K., Nash A. A., Wildy P., Phelan J., Mclean C. S., Field H. J. 1982; Pathogenesis of herpes simplex virus in congenitally athymic mice: the relative roles of cell-mediated and humoral immunity. Journal of General Virology 60:225–233
    [Google Scholar]
  7. Kristensson K., Suennerholm B., Persson L., Vahalne A., Lycke E. 1979; Latent herpes simplex virus trigeminal ganglionic infection in mice and demyelination in the central nervous system. Journal of the Neurological Sciences 43:253–264
    [Google Scholar]
  8. Merigan T. C., Stevens D. A. 1971; Viral infections in man associated with acquired immunological deficiency states. Federation Proceedings 30:1858–1864
    [Google Scholar]
  9. Morahan P. G., Thomson T. A., Kohl S., Murray B. K. 1981; Immune responses to labial infection of Balb/c mice with herpes simplex virus type 1. Infection and Immunity 32:180–187
    [Google Scholar]
  10. Nash A. A., Field H. J., Quartey-Papafio R. 1980 a; Cell-mediated immunity in herpes simplex virus-infected mice: induction, characterization and antiviral effects of delayed type hypersensitivity. Journal of General Virology 48:351–357
    [Google Scholar]
  11. Nash A. A., Quartey-Papafio R., Wildy P. 1980 b; Cell-mediated immunity in herpes simplex virus-infected mice: functional analysis of lymph node cells during periods of acute and latent infection with reference to cytotoxic and memory cells. Journal of General Virology 49:309–317
    [Google Scholar]
  12. Nash A. A., Phelan J., Wildy P. 1981; Cell-mediated immunity in herpes simplex virus-infected mice. H-2 mapping of the delayed-type hypersensitivity response and the antiviral T cell response. Journal of Immunology 126:1260–1262
    [Google Scholar]
  13. Oakes J. E. 1975; Role of cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection. Infection and Immunity 12:166–172
    [Google Scholar]
  14. Oakes J. E., Lausch R. N. 1981; Role of Fc fragments in antibody-mediated recovery from ocular and subcutaneous herpes simplex virus infections. Infection and Immunity 33:109–114
    [Google Scholar]
  15. Oldstone M. B. A., Lampert P. W. 1979; Antibody mediated complement dependent lysis of virus infected cells. Springer Seminars in Immunopathology 2:261–283
    [Google Scholar]
  16. Rager-Zisman B., Allison A. C. 1976; Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection. Journal of Immunology 116:35–40
    [Google Scholar]
  17. Russell W. C. 1962; A sensitive and precise plaque assay for herpes virus. Nature, London 195:1928–1929
    [Google Scholar]
  18. Shore S. L., Cromeans T. L., Romano T. J. 1976; Immune destruction of virus-infected cells early in the infectious cycle. Nature, London 262:695–696
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-61-1-127
Loading
/content/journal/jgv/10.1099/0022-1317-61-1-127
Loading

Data & Media loading...

Most cited Most Cited RSS feed