RT Journal Article SR Electronic(1) A1 Siegl, G. A1 Eggers, H. J.YR 1982 T1 Failure of Guanidine and 2-(α-Hydroxybenzyl)benzimidazole to Inhibit Replication of Hepatitis A Virus In vitro JF Journal of General Virology, VO 61 IS 1 SP 111 OP 114 DO https://doi.org/10.1099/0022-1317-61-1-111 PB Microbiology Society, SN 1465-2099, AB SUMMARY Replication of hepatitis A virus (HAV) in the human hepatoma-derived PLC/PRF/5 cell line was neither inhibited in the presence of various concentrations of guanidine or D-2-(α-hydroxybenzyl)benzimidazole (D-HBB), nor were the two chemicals effective in combination. Under identical conditions, however, replication of poliovirus type 1 was inhibited. Tracer experiments with radiolabelled guanidine and D-HBB also furnished no evidence that the two antiviral substances were metabolized gradually to inactive derivatives in PLC/PRF/5 cells. Therefore, it is concluded that resistance to the action of guanidine and D-HBB is an inherent characteristic of HAV. However, the insensitivity of HAV to these drugs does not exclude the virus from the family of picornaviruses., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-61-1-111