1887

Abstract

SUMMARY

It has been shown previously that the pathogenicity of avian influenza A viruses depends strictly on the proteolytic cleavability of their haemagglutinins (HAs) in infected cells. In this communication, pathogenic and non-pathogenic strains of the H7 subtype have been studied by comparing the genetic relatedness of their HA genes. Some of the cleavable HAs of pathogenic strains were genetically more closely related to the uncleaved HAs than to other cleavable HAs. These data clearly demonstrate that the overall evolution of the H7 haemagglutinins is different from the evolution of the specific cleavage site.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-61-1-101
1982-07-01
2021-10-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/61/1/JV0610010101.html?itemId=/content/journal/jgv/10.1099/0022-1317-61-1-101&mimeType=html&fmt=ahah

References

  1. Bosch F. X., Orlich M., Klenk H. D., Rott R. 1979; The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses. Virology 95:197–207
    [Google Scholar]
  2. Bosch F. X., Garten W., Klenk H.-D., Rott R. 1981; Proteolytic cleavage of influenza virus hemagglutinins: primary structure of the connecting peptide between HA, and HA2 determines proteolytic cleavability and pathogenicity of avian influenza viruses. Virology 113:725–735
    [Google Scholar]
  3. De Wachter R., Fiers W. 1972; Preparative two-dimensional polyacrylamide gel electrophoresis of 32P-labeled RNA. Analytical Biochemistry 49:184–197
    [Google Scholar]
  4. Fang R., Min Jou W., Huylebroeck D., Devos R., Fiers W. 1981; Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human Hong Kong 1968 influenza hemagglutinin. Cell 25:315–323
    [Google Scholar]
  5. Garten W., Bosch F. X., Linder D., Rott R., Klenk H.-D. 1981; Proteolytic activation of the influenza virus hemagglutinin. The structure of the cleavage site and the enzymes involved in cleavage. Virology 115:361–374
    [Google Scholar]
  6. Gething M.-J., Bye J., Skehel J. J., Waterfield M. D. 1980; Cloning and DNA sequence of double-stranded copies of hemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus. Nature, London 287:301–306
    [Google Scholar]
  7. Harms E., Rohde W., Bosch F. X., Scholtissek C. 1978; Biochemical studies on influenza viruses. II. Assignment of gene functions to RNA segments 5, 7, and 8 of fowl plague virus and virus N. Virology 86:413–422
    [Google Scholar]
  8. Hiti A. L., Davis A. R., Nayak D. P. 1981; Complete sequence analysis shows that the hemagglutinins of the H0 and H2 subtypes of human influenza virus are closely related. Virology 111:113–124
    [Google Scholar]
  9. Klenk H.-D., Rott R., Orlich M., BlÖdorn J. 1975; Activation of influenza virus by trypsin treatment. Virology 68:426–439
    [Google Scholar]
  10. Lazarowitz S. G., Choppin P. W. 1975; Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide. Virology 68:440–454
    [Google Scholar]
  11. Min Jou W., Verhoegen M., Devos R., Saman E., Fang R., Huylebroeck D., Fiers W., Threlfall G., Barber C., Carey N., Emtage S. 1980; Complete structure of the hemagglutinin gene from the human influenza virus A/Victoria/3/75 (H3N2) strain as determined from cloned DNA. Cell 19:683–696
    [Google Scholar]
  12. Porter A. G., Barber C., Carey N. H., Hallewell P. A., Threlfall G., Emtage J. S. 1979; Complete nucleotide sequence of an influenza virus hemagglutinin gene from cloned DNA. Nature, London 282:471–477
    [Google Scholar]
  13. Scholtissek C. 1979; The genes coding for the surface glycoproteins of influenza A viruses contain a small conserved region and a large variable region. Virology 93:594–597
    [Google Scholar]
  14. Scholtissek C., Harms E., Rohde W., Orlich M., Rott R. 1976; Correlation between RNA fragments of fowl plague virus and their corresponding gene functions. Virology 74:332–344
    [Google Scholar]
  15. Sleigh M. J., Both G. W., Bender V. J., Moss B. A. 1980 The hemagglutinin gene of influenza A virus: nucleotide sequence analysis of cloned DNA copies. In Structure and Variation in Influenza Virus pp. 69–78 Edited by Laver G., Air G. New York and Amsterdam: Elsevier/North-Holland;
    [Google Scholar]
  16. Ward C. W., Dopheide T. A. 1980 The Hong Kong (H3) hemagglutinin. Complete amino acid sequence and oligosaccharide distribution for the heavy chain of A/Memphis/102/72. In Structure and Variation in Influenza Virus pp. 27–38 Edited by Laver G., Air G. New York and Amsterdam: Elsevier/North-Holland;
    [Google Scholar]
  17. WORLD HEALTH ORGANIZATION MEMORANDUM 1980; A revision of the system of nomenclature for influenza viruses: a WHO memorandum. Bulletin of the World Health Organization 58585–591
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-61-1-101
Loading
/content/journal/jgv/10.1099/0022-1317-61-1-101
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error