1887

Abstract

Summary

Vero cells persistently infected with parainfluenza virus type 3 (para 3) were examined for the production of temperature-sensitive () mutants. After 6 months and 33 passages, mutants formed the great majority of the virus being shed into the supernatant fluid. Complementation studies gave evidence that the mutants shared a common lesion. Although mutants may play a role in the maintenance of persistent infection in this system, the mutants proved to be unstable when removed from the milieu of persistent infection. It is thus possible that their selection may be secondary to (an) unidentified factor(s) which play(s) a more primary role in the maintenance process.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-60-2-401
1982-06-01
2019-10-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-60-2-401
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error