@article{mbs:/content/journal/jgv/10.1099/0022-1317-60-2-397, author = "Bocci, V. and Pacini, A. and Bandinelli, L. and Pessina, G. P. and Muscettola, M. and Paulesu, L.", title = "The Role of Liver in the Catabolism of Human α- and β-Interferon", journal= "Journal of General Virology", year = "1982", volume = "60", number = "2", pages = "397-400", doi = "https://doi.org/10.1099/0022-1317-60-2-397", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-60-2-397", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "hepatic binding protein", keywords = "liver catabolism", keywords = "interferons", keywords = "asialointerferons", abstract = "SUMMARY The susceptibility of human leukocyte (α), fibroblast (β) and recombinant α-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant α-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that α-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human β-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.", }